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New drug aims to reduce deaths from severe lung failure

NCT ID NCT05947955

Recruiting now Disease control Sponsor: BioAegis Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive either the drug or a placebo, and researchers will measure how many survive at 28 days, how many days they need a ventilator, and other outcomes. The goal is to see if this drug can improve survival and recovery.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome Infections infectious disease respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY DISTRESS SYNDROME INFECTIONS

Contacts and locations

Locations

  • Asst-Spedali Civili di Brescia

    RECRUITING

    Brescia, 25123, Italy

  • Baylor Scott & White Health

    RECRUITING

    Temple, Texas, 76508, United States

  • Bellvitge University Hospital

    RECRUITING

    Barcelona, 08907, Spain

  • Bryan Medical Center

    RECRUITING

    Lincoln, Nebraska, 68506, United States

  • CHU Charleroi Marie Curie Hospital

    RECRUITING

    Charleroi, 6042, Belgium

  • CHU Nantes

    RECRUITING

    Nantes, 1, France

  • Canisius Wilhelmina Ziekenhuis

    RECRUITING

    Nijmegen, 6532 SZ, Netherlands

    Contact Email: •••••@•••••

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Centre Hospitalier Departemental (CHD) Vendee

    RECRUITING

    La Roche-sur-Yon, France

  • Centre Hospitalier Lyon Sud

    RECRUITING

    Oullins-Pierre-Bénite, 69495, France

  • Centre Hospitalier Regional de la Citadelle

    RECRUITING

    Liège, 4000, Belgium

  • Centre Hospitalier de Melun-Senart

    RECRUITING

    Melun, 77000, France

  • Centre intégré universitaire de santé et services sociaux du nord de l'île de Montréal-Hôpital du Sacré de Montréal (CIUSSS-NÎM-HSCM)

    RECRUITING

    Montreal, Quebec, H4J1C5, Canada

  • Clinical County Hospital Timisoara

    RECRUITING

    Timișoara, 300723, Romania

  • Clinique Saint-Pierre Ottignies

    RECRUITING

    Ottignies, 1340, Belgium

  • Clínico San Carlos

    RECRUITING

    Madrid, Spain

  • County Clinical Hospital Tirgu Mures

    RECRUITING

    Târgu Mureş, 540103, Romania

  • Derriford Hospital (University Hospitals Plymouth Hospital Trust)

    RECRUITING

    Plymouth, PL6 8DH, United Kingdom

  • Ferenc Csolnoky Hospital of Veszprem County

    RECRUITING

    Veszprém, H-8200, Hungary

  • Fondazione Policlinico A. Gemelli IRCCS

    RECRUITING

    Rome, 00165, Italy

  • Foothills Medical Centre

    RECRUITING

    Calgary, Alberta, AB T2N 5A1, Canada

  • Gelderse Vallei Hospital

    RECRUITING

    Ede, Netherlands

  • Gelre Hospitals, Department of ICU

    RECRUITING

    Apeldoorn, Netherlands

  • General University Hospital

    RECRUITING

    Prague, 2, 12000, Czechia

  • Grey Nuns Hospital

    RECRUITING

    Edmonton, Alberta, T6L 5X8, Canada

  • HUB - Hôpital Erasme

    RECRUITING

    Brussels, 1070, Belgium

  • Hannibal Regional Hospital

    RECRUITING

    Hannibal, Missouri, 63401, United States

  • Hopital Pitie-Salpetriere

    RECRUITING

    Paris, 75013, France

  • Hospital Clínic Barcelona

    RECRUITING

    Barcelona, 08030, Spain

  • Hospital Universitari Sant Joan de Reus

    RECRUITING

    Tarragona, 43204, Spain

  • Hospital Universitari de Tarragona Joan XXIII

    RECRUITING

    Tarragona, 43005, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario de Getafe

    RECRUITING

    Madrid, 28905, Spain

  • Hospital of Siofok

    RECRUITING

    Siófok, 8600, Hungary

  • Hôpital du Kremlin Bicêtre, APHP

    RECRUITING

    Le Kremlin-Bicêtre, 94275, France

  • Jena University Hospital

    RECRUITING

    Jena, 07747, Germany

  • Jeroen Bosch Ziekenhuis

    RECRUITING

    's-Hertogenbosch, Netherlands

  • Lions Gate Hospital

    RECRUITING

    North Vancouver, British Columbia, V7L 2L7, Canada

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • McGill University Health Centre - Royal Victoria Hospital (MUHC-RVH)

    RECRUITING

    Montreal, Quebec, H4A 3J1, Canada

  • McGovern Medical School - UT Physicians Pulmonary Medicine - Texas Medical Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Medisch Spectrum Twente

    RECRUITING

    Enschede, 7512 KZ, Netherlands

  • National Institute of Pulmonology

    RECRUITING

    Budapest, H-1121, Hungary

  • New York University Grossman School of Medicine

    NOT_YET_RECRUITING

    New York, New York, 10016, United States

  • Northwestern University - Pulmonary and Critical Care Medicine

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Nouvel Hopital Civil

    NOT_YET_RECRUITING

    Strasbourg, 67091, France

  • Penn State Health - Milton S. Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

  • Penn State Health - Milton S. Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

  • Peter Lougheed Centre

    RECRUITING

    Calgary, T1Y 6J4, Canada

  • Pinderfields Hospital (Mid Yorkshire Teaching NHS Trust)

    RECRUITING

    Wakefield, WF1 4DG, United Kingdom

  • Rocky View General Hospital

    RECRUITING

    Calgary, T2V 1P9, Canada

  • Saarland University Hospital

    RECRUITING

    Homburg, 66421, Germany

  • South Health Campus

    RECRUITING

    Calgary, T3M 1M4, Canada

  • Spital Universitar de Urgenta ELIAS (University Emergency Hospital Elias)

    RECRUITING

    Bucharest, Romania

  • St. Anne's University Hospital

    RECRUITING

    Brno, 602 00, Czechia

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

  • Szabolcs-Szatmar-Bereg County Teaching Hospital, Andras Josa Hospital

    RECRUITING

    Nyíregyháza, H-4400, Hungary

  • Szent Damján Greek Catholic Hospital

    RECRUITING

    Kisvárda, 4600, Hungary

  • Tenon Hospital

    RECRUITING

    Paris, 75020, France

  • UMHAT "Alexandrovska" EAD

    RECRUITING

    Sofia, Bulgaria

  • University Health Network (UHN)-Toronto General Hospital (TGH)

    RECRUITING

    Toronto, Ontario, M5G 2N2, Canada

  • University Hospital Královské Vinohrady

    RECRUITING

    Prague, 100 34 10, Czechia

  • University Hospital LMU Munich

    RECRUITING

    Munich, D-81377, Germany

  • University Hospital of Bucharest

    RECRUITING

    Bucharest, 050098, Romania

  • University Hospital of Bucharest

    RECRUITING

    Barcelona, 08208, Spain

  • University Hospital of Wales

    RECRUITING

    Cardiff, CF14 4XW, United Kingdom

  • University of Louisville Hospital - Jewish Hospital

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • University of Louisville-Jewish Hospital

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • University of Pittsburgh Medical Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15261, United States

  • Wellstar MCG Augusta University

    RECRUITING

    Augusta, Georgia, 30912, United States

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