Could a simple supplement save feverish kids in poor countries?

NCT ID NCT06426147

Recruiting now Disease control Sponsor: Barcelona Institute for Global Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving L-Citrulline, a natural supplement, for 28 days can help hospitalized children aged 1 month to 5 years who have fever and are at high risk of serious problems. About 888 children in Mozambique and Ethiopia will receive either the supplement or a placebo. The goal is to see if it reduces death, organ failure, or other severe outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: L-Citrulline (a dietary supplement)
What this could lead to: If it works, this could provide a simple, low-cost supplement to reduce deaths and serious complications in hospitalized children with fever in low-resource settings.
What could go wrong: This is an early-stage trial with no phase designation, and the supplement may not show benefit over placebo. Results may not apply to other settings or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

CHILD syndrome Infections infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILD, ONLY INFECTIONS INFECTIOUS DISEASE

Contacts and locations

Locations

Hararghe Health Research
RECRUITING

Harar, Ethiopia
Hospital Central de Maputo
RECRUITING

Maputo, Mozambique

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