Pill power: could oral antibiotics replace IV for tough bone infections?
NCT ID NCT05699174
First seen Feb 02, 2026 · Last updated Jun 23, 2026 · Updated 12 times
Summary
This study tests whether taking antibiotic pills is as effective as getting them through an IV for treating infected bone fractures that didn't heal properly. About 250 adults with this condition will be randomly assigned to either oral or IV antibiotics for up to 6 weeks after surgery. The goal is to see if the oral route leads to fewer hospital readmissions and similar infection control.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Atrium Health, Carolinas Medical Center
NOT_YET_RECRUITINGCharlotte, North Carolina, 28207, United States
Contact Email: •••••@•••••
Contact
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Hennepin Health
RECRUITINGMinneapolis, Minnesota, 55487, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Email: •••••@•••••
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Jamaica Hospital Medical Center
NOT_YET_RECRUITINGQueens, New York, 11418, United States
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Penn State University M.S. Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact Email: •••••@•••••
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Sinai Hospital Baltimore
NOT_YET_RECRUITINGBaltimore, Maryland, 21215, United States
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University of Maryland , MD Department of Orthopaedics
RECRUITINGBaltimore, Maryland, 21201, United States
Contact
Contact Email: •••••@•••••
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University of Okalahoma College of Medicine
NOT_YET_RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Contact Email: •••••@•••••
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University of Texas Health Science Center at Houston
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington Harborview Medical Center
RECRUITINGSeattle, Washington, 98195, United States
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University of Wisconsin
RECRUITINGMadison, Wisconsin, 53705, United States
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Vanderbilt Medical Center
RECRUITINGNashville, Tennessee, 37203, United States
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Wake Forest University Baptist Medical Center
RECRUITINGWinston-Salem, North Carolina, 27106, United States
Contact Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antibiotics (oral or intravenous)
What this could lead to
If oral antibiotics work as well as IV, patients could avoid hospital stays and IV lines, making treatment easier and cheaper.
What could go wrong
This is a mid-stage trial with 250 patients, so results may not apply to everyone. Oral antibiotics might not clear deep bone infections as effectively as IV, risking treatment failure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.