INFECTIONS

This study is testing a new vaccine called GNG-DE to see if it safely protects people from four dangerous types of meningococcal bacteria (A, C, Y, W135). Researchers will compare it to an existing vaccine in 240 healthy volunteers aged 3 to 55. The main goal is to see if the new…

This study is testing whether Mozobil, a drug already used for other conditions, can safely improve low white blood cell counts in adults with WHIMS syndrome. WHIMS is a rare genetic disorder where the immune system doesn't work properly, leading to frequent infections, warts, an…

This study is testing if a nutritional supplement called L-Citrulline can help young children hospitalized with serious infections. About 888 children in Mozambique and Ethiopia who are at high risk for severe complications will receive either the L-Citrulline syrup or a placebo …

This study is testing whether adding an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) to standard hospital care can help patients with severe Acute Respiratory Distress Syndrome (ARDS) caused by infections like pneumonia. ARDS is a life-threatening conditi…

This study aims to help babies with serious infections like sepsis get the right dose of a key antibiotic (vancomycin) faster. Currently, doctors must wait 1-2 days to check if the dose is correct, delaying optimal treatment. Researchers are testing if checking drug levels after …

This project is testing a new team-based approach to improve care for people with infections in their implanted heart devices, like pacemakers. It aims to help doctors identify these infections earlier, follow treatment guidelines better, and remove infected devices more quickly.…

This study is testing whether a special bandage called PowerHeal™, which creates a tiny electric field, can help infected wounds heal better. Researchers will compare it to standard wound dressings in 150 patients in Ukraine with infected traumatic injuries. The main goals are to…

This study is testing a new program in nursing homes to improve how suspected infections are managed in residents with dementia. It aims to see if the program can safely reduce the use of antibiotics and avoid stressful hospital trips and tests. The study will involve about 750 r…

This study is testing whether taking antibiotic pills by mouth for 6 weeks works as well as receiving antibiotics through an IV drip to treat infected bone fractures that have not healed after surgery. It will involve 250 adults who have this complication. The goal is to see if t…

This study is testing a new augmented reality (AR) system designed to help doctors during MRI-guided needle procedures, like biopsies or injections. The AR system projects a visual guide onto the patient, showing the doctor the best path for the needle. Researchers want to see if…

This study is testing whether sputum (mucus) samples collected at home and mailed to a lab are as good as samples collected in a clinic for detecting lung infections in adults with cystic fibrosis (CF). It aims to make infection monitoring easier and more accessible, especially a…

This study aims to find new blood markers that can help doctors diagnose sepsis more quickly and accurately when patients arrive at the emergency room with suspected infections. Researchers will follow 3,300 patients to compare immune responses in those with and without sepsis, a…

This study aims to develop and improve new portable blood testing devices. Researchers will collect small blood samples from up to 20,000 adults with various health conditions to see if the new portable tests are as accurate as standard lab tests. The goal is to create faster, ea…

This study is testing if a single dose of the antibiotic azithromycin, given to pregnant women before their labor is medically induced, can prevent infections in both the mother and baby. It will involve 400 women in their third trimester who are scheduled for labor induction. Re…

This study is following women who received an experimental vaccine against Group B Streptococcus (GBS) during a past pregnancy. The main goals are to see how long their immune protection lasts and to check the safety and effectiveness of giving a booster dose if they become pregn…

This study is testing if a special nasal light treatment given right before surgery can help prevent wound infections. It will compare the treatment to standard care in about 4,740 adults having major surgeries like heart, bone, or brain operations. The main goal is to see if the…

This study is testing whether a 10-week parenting support program can help prevent common health problems in low-income Latino infants. Researchers will enroll 260 mothers and their 9-month-old babies to compare the parenting program against a book-sharing program. They will trac…

This large study is testing whether a special nasal light treatment can prevent dangerous infections at the surgical wound site. Over 4,500 patients having major surgeries like heart, bone, or brain operations will receive either this new treatment or standard care. The goal is t…

This study is testing a new hospital safety program designed to prevent sepsis, a life-threatening infection that is a leading cause of death for mothers during and after childbirth. The program involves training staff, improving how sepsis is spotted and treated, and incorporati…

This early-stage study aims to understand how a new antibiotic combination reaches different parts of the lungs in healthy adults. Researchers will measure drug levels in blood, lung fluid, and immune cells after intravenous administration. The study involves 16 healthy Chinese p…

This study aims to understand the data from HeartMate 3 heart pumps to see if it can predict medical problems and improve patients' quality of life. Researchers will collect data from 150 adults who have received this specific pump, looking for patterns that might warn of issues …

This study aims to better understand serious Bacillus cereus infections in premature babies hospitalized in France. Researchers will analyze bacteria samples from 40 infected newborns to identify which strains are most dangerous and what factors lead to worse outcomes. The goal i…

This study aims to understand why infections are common after surgery to remove esophageal cancer and how they affect recovery. Researchers will look back at the medical records of 350 patients who had this surgery in France between 2017 and 2024. By identifying risk factors for …

This study aims to find out how common certain infections are among adult asylum seekers who have been in Italy for 2 to 36 months. Researchers will screen 250 people at a reception center for diseases like tuberculosis, HIV, hepatitis, and parasitic worms. The goal is to gather …

This study aims to develop a personalized immune score to predict which immunocompromised patients (like transplant recipients) are at highest risk for severe infections. Researchers will measure various immune cells and responses in 150 patients before or shortly after their tra…

This study aims to learn more about Hyper IgE Syndrome, a rare immune disorder that causes severe eczema and frequent infections. Researchers will observe 300 patients and 300 of their relatives over time to understand how the disease develops, identify its genetic causes, and im…

This study aims to collect long-term data on how well shoulder replacement implants work and how safe they are over many years. It will follow up to 20,000 patients who have had or will have shoulder replacement surgery for at least 10 years. Researchers will track patients' pain…