Could a single IV antibiotic dose send kids home sooner?

NCT ID NCT04876131

Recruiting now Disease control Sponsor: Murdoch Childrens Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolving symptoms within 72 hours. If it works, it could reduce hospital stays and the risks of unnecessary IV treatment. The trial involves 452 children aged 3 months to 18 years with complicating factors like vomiting or urological issues.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics (benzylpenicillin and gentamicin)
What this could lead to: If successful, this could shorten hospital stays for children with complicated UTIs by allowing them to go home sooner on oral antibiotics.
What could go wrong: This is a phase 4 trial, but it's still possible that a single IV dose may not control the infection as well as three doses, leading to prolonged symptoms or treatment failure.

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Conditions

The condition(s) this trial relates to.

bacterial urinary tract infection Infections infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPLICATED URINARY TRACT INFECTION INFECTION PEDIATRIC INFECTIOUS DISEASE

Contacts and locations

Locations

Flinders Medical Centre
RECRUITING

Adelaide, South Australia, 5042, Australia
Monash Health
RECRUITING

Melbourne, Victoria, 3168, Australia
Perth Children's Hospital
RECRUITING

Perth, Washington, 6009, Australia
Royal Children's Hospital
RECRUITING

Parkville, Victoria, 3052, Australia
Starship Children's Hospital
RECRUITING

Auckland, Auckland Province, 1023, New Zealand
University Hospital Geelong
RECRUITING

Geelong, Victoria, 3220, Australia
Women and Children's Hospital
RECRUITING

Adelaide, South Australia, Australia

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