Could a single IV antibiotic dose send kids home sooner?
NCT ID NCT04876131
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolving symptoms within 72 hours. If it works, it could reduce hospital stays and the risks of unnecessary IV treatment. The trial involves 452 children aged 3 months to 18 years with complicating factors like vomiting or urological issues.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antibiotics (benzylpenicillin and gentamicin)
What this could lead to
If successful, this could shorten hospital stays for children with complicated UTIs by allowing them to go home sooner on oral antibiotics.
What could go wrong
This is a phase 4 trial, but it's still possible that a single IV dose may not control the infection as well as three doses, leading to prolonged symptoms or treatment failure.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Monash Health
RECRUITINGMelbourne, Victoria, 3168, Australia
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Perth Children's Hospital
RECRUITINGPerth, Washington, 6009, Australia
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Children's Hospital
RECRUITINGParkville, Victoria, 3052, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Starship Children's Hospital
RECRUITINGAuckland, Auckland Province, 1023, New Zealand
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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University Hospital Geelong
RECRUITINGGeelong, Victoria, 3220, Australia
Contact Email: •••••@•••••
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Women and Children's Hospital
RECRUITINGAdelaide, South Australia, Australia
Contact Email: •••••@•••••
Contact Email: •••••@•••••