INFECTION

This early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. …

This study tests whether monitoring levels of a harmless virus called TTV can help doctors personalize immune-suppressing drugs for kidney transplant patients. The goal is to prevent long-term complications like infections, cancer, and organ rejection. About 600 adults who receiv…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests whether copper supplements can improve liver function and safety in people with cirrhosis who have low copper levels. Researchers will give 30 participants either copper or a placebo and measure changes in blood copper levels and other health markers. The goal is…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests a special device called PIVO Pro that lets doctors draw blood for infection tests through an IV line already in the arm, avoiding extra needle sticks. The goal is to see if this method reduces contamination of the blood sample compared to the usual way. About 1,1…

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This study is testing a new knee replacement system called Persona Revision for people who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. About 380 adults will be followed for two years after surgery.

This study tests a new, non-invasive tool called the POP-Score to predict infection in newborns within the first 6 hours of life. The score combines light-based measurements of muscle oxygen with routine vital signs like heart rate and blood pressure. Researchers will enroll 93 n…

This study is testing whether a blood test called Karius Spectrum can help doctors find infections faster in adults with weakened immune systems (e.g., organ transplant recipients, cancer patients). The test looks for DNA from bacteria, fungi, viruses, and parasites in the blood.…

This study tests a new diagnostic method called metagenomic sequencing to find hidden infections in people with eye inflammation (uveitis). Standard tests often miss the cause. Researchers will analyze fluid from the eye to detect bacteria, viruses, fungi, or parasites. The goal …

This study tests different methods to stop the spread of dangerous bacteria in operating rooms and reduce infections after surgery. About 6,000 people having hip, knee, or spine surgery will take part. The goal is to find the best way to keep patients safe from infections.

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study enrolls up to 400 people with known or suspected infections or inflammatory diseases that are not covered by other research protocols. The goal is to evaluate patients using standard medical practices, generate new ideas for future studies, and train doctors. No experi…

This study is testing a risk prediction model for MDRGNB, a type of drug-resistant infection, in 1,000 ICU patients across multiple hospitals. Researchers will check how well the model predicts who gets infected, using data collected within 48 hours of ICU admission. The goal is …

This study checks whether lab tests that measure drug levels in body fluids are accurate and reliable. Researchers will collect blood, urine, and other samples from 100 adults who are taking certain medicines (like antibiotics, antivirals, birth control, or erectile dysfunction d…

This study tests whether patients with serious infections who are at risk for sepsis can be safely monitored at home using wearable devices and a smartphone app. About 120 adults will take part, and the goal is to see if this approach can reduce hospital visits while still catchi…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study is checking for antibiotic-resistant bacteria in the gut of 200 people who take PrEP (HIV prevention pills). Researchers will collect rectal swabs during routine STI testing and analyze the bacteria for resistance. The goal is to understand how common resistance is in …

This study tests whether using changes in procalcitonin levels over time (kinetics) is better than a single measurement for deciding when to start antibiotics in critically ill patients with suspected infection. About 250 adults in the ICU will be randomly assigned to one of two …

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…

This study tests whether an educational program can help doctors in intensive care units (ICUs) use fewer antibiotics. The program includes training sessions and feedback based on the latest guidelines. Researchers will compare antibiotic use in ICUs before and after the program,…

This study is testing whether wearable devices (like smartwatches) can help catch infections early in children receiving cancer treatment. About 150 kids aged 5-18 will wear a device for 4 weeks to track heart rate, activity, and other health signs. The goal is to build a compute…