INFECTION

This study tested whether using a suction toothbrush for oral care could reduce ventilator-associated pneumonia (VAP) in intubated ICU patients. 111 adults on breathing machines were randomly assigned to cleaning with distilled water or a chlorhexidine solution using the suction …

This study compared two ways of taking prostate tissue samples: the standard transrectal method (through the rectum) and a newer transperineal method (through the skin between the scrotum and anus). Over 1,000 men participated to see if the transperineal approach causes fewer inf…

This study tested whether applying vancomycin powder directly to the surgical wound during brain surgery can reduce infections. Over 1,100 adults having neurosurgery were randomly assigned to receive either the topical vancomycin or standard care. The main goal was to see if the …

This phase 3 trial tested whether giving a special nutritional supplement (immunonutrition) before and after surgery could reduce infections in 311 patients with head and neck cancer. Participants were randomly assigned to one of three nutrition regimens. The main goal was to see…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

This study tested whether a quick fingerstick blood test for D-Dimer (clot marker) and CRP (inflammation marker) gives the same results as standard lab tests using blood from a vein. Researchers enrolled 111 adults and compared results from fingerstick, venous whole blood, and pl…

This study tested a simple strip test called PeriScreen to quickly diagnose infection in the belly fluid of people with cirrhosis. The goal is to see if the strip can spot infections as accurately as standard lab tests, helping doctors start treatment faster. About 649 adults wit…

This completed study tested a new rapid diagnostic tool to quickly identify antibiotic-resistant bacteria in wounded warriors and veterans. Over 2,200 participants provided samples from blood, lungs, or skin. The goal was to see if the test could accurately detect resistant bacte…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested a 60% ethanol (alcohol) lock solution to prevent serious catheter infections in 1,460 ICU patients with acute kidney failure needing dialysis. The ethanol lock is placed inside the catheter to kill germs. The goal was to see if it reduces major catheter-related …

This study tested whether far-UVC light (222 nm) can reduce infections in elderly nursing home residents. Over 600 residents in 12 Danish facilities took part. Some facilities used the light in common areas or apartments, while others received standard care. The goal was to see i…

This study surveys medical students to understand their attitudes toward tattoos and piercings and measure their awareness of related skin risks, such as infections, allergic reactions, and scarring. Researchers aim to see if students have adequate knowledge and how their views d…

This study looked at 68 newborns to see if a non-invasive light sensor, which measures blood flow under the skin (called perfusion index), could help spot infections early. Newborn infections are hard to detect because signs are subtle, and delays can be dangerous. The researcher…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This study looked at 275 adults with a lung condition called bronchiectasis, where airways are stretched and trap mucus, leading to infections. The goal was to learn more about the physical traits, lung scans, and germs in the lungs of people with the unexplained form of the dise…

This study looked at how the body processes an antibiotic called piperacillin in intensive care patients who are on a life-support machine (ECMO) compared to those who are not. Researchers wanted to see if ECMO changes antibiotic levels, which could affect how well the drug fight…

This early-phase study in 40 healthy adults explores how the immune system reacts to the non-toxic part of cholera toxin (CTB) when given through the nose, mouth, or under the tongue. The goal is to understand mucosal immune responses, which could help in developing future vaccin…

This completed study looked at whether screening hospital patients for multidrug-resistant gram-negative bacteria can predict if they will later develop an infection. Researchers reviewed records of nearly 2,900 adults admitted to an acute care hospital. The goal was to see if ea…

This study looked at two different ways of giving the antibiotic cloxacillin to treat bone and joint infections caused by Staphylococcus aureus bacteria. Twelve patients received the drug both as a steady drip (continuous infusion) and as short doses (intermittent infusion) to se…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study tested a new single-use duodenoscope (aScope) in 59 patients at high risk of infection after ERCP, a procedure to treat bile duct problems. The goal was to see if the scope works well and to gather information on costs and complications. The results could help decide i…

This study compared two common methods for taking a prostate biopsy: one through the rectal wall and one through the skin between the scrotum and anus. 840 men who needed a biopsy for suspected prostate cancer were randomly assigned to one of the two methods. The goal was to see …

This study followed 196 patients who had jaw-lengthening surgery to see if using a calcium phosphate paste leads to more infections or hardware removal. The paste is meant to prevent a visible notch and improve stability. The goal was to weigh these benefits against any added ris…