Could a mouthwash replace a tube down your throat to diagnose pneumonia?

NCT ID NCT00342589

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 10 times

Summary

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researchers will compare the oral rinse method with standard tests in over 1,000 participants, including patients with HIV, cancer, or organ transplants, as well as healthy volunteers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple, non-invasive oral rinse test for diagnosing pneumocystis pneumonia, replacing uncomfortable procedures like bronchoscopy.
What could go wrong
This is an early diagnostic study, not a treatment trial. The oral wash may not detect enough organisms to be reliable, and results may not change current clinical practice.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

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