Could a mouthwash replace a tube down your throat to diagnose pneumonia?
NCT ID NCT00342589
First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 10 times
Summary
This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researchers will compare the oral rinse method with standard tests in over 1,000 participants, including patients with HIV, cancer, or organ transplants, as well as healthy volunteers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple, non-invasive oral rinse test for diagnosing pneumocystis pneumonia, replacing uncomfortable procedures like bronchoscopy.
- What could go wrong
- This is an early diagnostic study, not a treatment trial. The oral wash may not detect enough organisms to be reliable, and results may not change current clinical practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INFECTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Aging in place: could mobile teams keep nursing home residents out of the hospital?
- A pillow shaped to protect the spine after surgery — a small trial puts it to the test
- Drone Warfare's hidden toll: new study tracks infection risk in combat wounds
- Rapid molecular tests could help doctors prescribe antibiotics more precisely
- Do future doctors know the skin risks of tattoos and piercings?
- Genetic test could shorten hospital stays for fungal infection patients