INFECTION

This study looks at how well the antibiotic aztreonam-avibactam works in real hospital settings for patients with serious infections caused by multidrug-resistant bacteria. About 100 critically ill adults will be followed to see if the drug clears the infection without the need f…

This study tests whether a home-based rapid response team can safely reduce the number of days adults spend in the hospital for suspected infections. About 500 participants are randomly assigned to either standard hospital care or a home assessment and treatment pathway. The goal…

This study tests whether an iodine-coated barrier dressing placed on the skin before surgery can reduce bacteria and prevent infections in people getting a new or upgraded heart device (like a pacemaker). About 390 adults at higher risk for infection are randomly assigned to get …

This study looks at a new way to diagnose infections in broken bones using a DNA sequencing technology called Nanopore. Researchers will compare this method to standard lab cultures to see if it is faster and more accurate. The goal is to help doctors choose the right antibiotics…

This study looks at whether putting antibiotic powder directly into the joint during knee or hip replacement surgery can prevent infections better than just giving antibiotics through a vein. About 1,832 adults having a first-time or aseptic revision joint replacement will be ran…

This study looked at using a computer program (machine learning) to predict how long patients would stay in a home hospital. Researchers used information from past patients, like their health conditions and background, to train the computer model. The goal was to see if the model…

This study looks at 120 adults receiving a left ventricular assist device (LVAD), a mechanical heart pump. Researchers want to understand how often infections happen after surgery and how the immune system changes. The goal is to find risk factors that could predict who might get…

This study planned to use a computer program (machine learning) and a simple heart test (single-lead ECG) to predict potassium levels in the blood of hospitalized patients. Researchers would have analyzed data from a previous study at Brigham and Women's Hospital. However, the st…

This study looks back at 4000 patients who had a viral infection in the brain or spinal cord. Researchers want to see how the infection and recovery differ between children, adults, and people with weak immune systems. The goal is to help doctors diagnose and treat these infectio…

This study will enroll 40 children aged 8-18 with Familial Mediterranean Fever (FMF) to see if a mobile app can help track infection symptoms and predict disease flares. Participants will record symptoms daily, and researchers will analyze the link between infections and attacks.…