Joint surgery infection breakthrough? vancomycin powder put to the test
NCT ID NCT04399642
First seen Oct 31, 2025 · Last updated Jun 21, 2026 · Updated 37 times
Summary
This study compares infection rates in about 1,800 adults having hip or knee replacement surgery. Half get standard IV antibiotics before surgery, and the other half get the same IV antibiotics plus vancomycin powder placed directly into the joint. The goal is to see if the added powder reduces acute and long-term infections.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INFECTION are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Hopital Sacré-Coeur de Montreal
Montreal, Quebec, H4J 1C5, Canada
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vancomycin powder
What this could lead to
If it works, this could point toward a simple, low-cost way to reduce infections after joint replacement surgery.
What could go wrong
This is a single study with results not yet reported. The added antibiotic may not lower infection rates and could carry risks like allergic reactions or antibiotic resistance.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.