INFECTION

This study tests a needle-free device (PIVO Pro) that draws blood through an existing IV line, aiming to reduce contamination in blood cultures. About 1,148 adults in emergency departments will be randomly assigned to either the new device or the usual needle stick method. The go…

This early-stage study tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people unable to fight off infections. Researchers take a participant's own white blood cells, add a corrective mRNA instruction, and return the cells to the body.…

This study tests whether treating suddenly ill adults at home is as safe and effective as hospital care. About 3,000 participants with conditions like infections, heart failure, or COPD will receive hospital-level care at home. The goal is to see if home care can lower costs and …

This study is testing a new knee replacement system called Persona Revision in 380 adults who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. Participants will be followed for 2 years after surgery.

This study tests whether giving copper supplements to people with cirrhosis (scarred liver) and low copper levels can improve liver function and reduce infections. About 30 adults with cirrhosis and low blood copper will receive either copper or a placebo for several weeks, then …

This study tests whether a blood test called Karius Spectrum can help doctors find the cause of an infection faster in people with weakened immune systems. About 2,000 adults with conditions like organ transplants or cancer will give one blood sample. The goal is to see if this t…

This study tests a new, non-invasive tool called the POPScore to predict infections in newborns with breathing problems. The score combines light measurements of muscle oxygen with routine vital signs like heart rate. Researchers will check if the score, taken within 6 hours of b…

This study tests a powerful DNA test called metagenomic sequencing on fluid from the eyes of 36 adults with unexplained inflammation. The goal is to find hidden infections that standard tests miss. If successful, this could lead to better, targeted treatments for people with eye …

This study tests a program to stop the spread of dangerous bacteria (ESKAPE) that cause infections after surgery. About 6,000 people having hip, knee, or spine surgery will take part. The program uses improved cleaning and monitoring to reduce infections, which could make surgery…

This study compares two treatment plans for children with complicated urinary tract infections (UTIs). One group gets a single IV antibiotic dose followed by two days of oral antibiotics, while the other gets three daily IV doses. The goal is to see if the shorter IV course works…

This study tests whether giving antibiotics continuously through a small pump is safe and cost-effective for children with serious bacterial infections. About 150 children who are stable enough to be at home will receive the pump instead of multiple daily injections. The goal is …

This study checks if lab tests that measure drug levels in body fluids are accurate and reliable. Researchers will collect samples from 100 adults, some taking medications and some not. No new treatment is given; the goal is to improve testing methods.

This study compares two ways of giving the antibiotic cefepime to ICU patients with sepsis or infection. The new method uses available doses but adjusts them based on the patient's kidney function. The main goal is to see how easy the new method is for doctors to use, and if it h…

This study aims to see if an educational program for ICU doctors can reduce the amount of antibiotics given to critically ill patients. Researchers will compare antibiotic use in ICUs during months with and without the program. The study involves about 9000 patients across multip…

This study looks at people with known or suspected inflammatory or infectious diseases that aren't covered by other research protocols. The goal is to evaluate and treat these patients using standard medical practices while gathering information to help train doctors and design f…

This study aims to understand how common antibiotic-resistant bacteria are in the gut of people using PrEP (HIV prevention medication). Researchers will collect samples from 200 HIV-negative adults aged 18-45 during routine check-ups. The goal is to gather data that could lead to…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious problems like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections for 28 days to see how well these e…

This study is testing whether wearable devices like smartwatches can help detect infections early in children receiving cancer treatment. About 150 kids aged 5-18 will wear a device that tracks heart rate, activity, and other health signs for 4 weeks. Researchers will use this da…

This study looks at whether a special hospital unit called an Acute Medical Unit (AMU) can provide better care for older adults with sudden illnesses like infections, falls, or COPD flare-ups. Researchers will compare patients who go to the AMU with those who get usual hospital c…

This study tests whether people with serious infections can be safely monitored at home using wearable devices and a smartphone app, instead of staying in the hospital. The goal is to catch early signs of sepsis—a life-threatening reaction to infection—so doctors can step in quic…

This study looks at whether a protein called vasorin in the blood can help doctors tell the difference between septic shock (caused by infection) and other types of shock. Researchers will measure vasorin levels in 144 intensive care patients and compare them with standard tests.…

This study tests whether looking at how a blood marker (procalcitonin) changes over time is better than a single measurement for deciding when to start antibiotics in critically ill patients. About 250 adults in the ICU with a suspected infection will be randomly assigned to one …