INFECTION

This early-stage study is testing a one-time treatment for Chronic Granulomatous Disease (CGD), a rare genetic disorder where the immune system cannot fight infections properly. Researchers will collect a patient's white blood cells, use messenger RNA (mRNA) to temporarily fix th…

This study is testing whether suddenly ill adults with conditions like infections, heart failure, or breathing problems can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care at home with doctors, nurses, tests, and treat…

This study is testing whether a new, more personalized method for dosing a common antibiotic (cefepime) works better for very sick patients in the ICU with serious infections like sepsis. The main goal is to see if doctors and nurses find the new dosing method easy to use in a re…

This small pilot study is testing whether giving copper supplements to people with advanced liver scarring (cirrhosis) is safe and can improve their health. It will involve 30 adult patients who have cirrhosis and low copper levels. Researchers want to see if raising copper level…

This study is comparing two antibiotic treatments for children with complicated urinary tract infections (UTIs). It will test if a single dose of IV antibiotics followed by pills is as effective as three days of IV antibiotics. The goal is to see if kids can get better just as qu…

This study is testing a specific replacement knee implant system designed for patients who have had problems with a previous knee replacement. It aims to see if the new implant improves knee function, reduces pain, and is safe over time. Researchers will follow about 380 patients…

This study is testing if tracking how a blood marker called procalcitonin changes over time is better than using a single high reading to decide when to start antibiotics in intensive care patients with a suspected infection. It aims to reduce unnecessary antibiotic prescriptions…

This study is testing if a new blood test, called the Karius Spectrum test, can help doctors identify the specific cause of an infection faster than current standard tests alone. It involves 2,000 adult participants with weakened immune systems, such as organ transplant recipient…

This study is testing a new diagnostic method to find infections that might be causing serious eye inflammation when standard tests can't find a cause. Researchers will analyze fluid from the eyes of 36 adults with unexplained inflammation, using a technique that can detect nearl…

This study aims to see if a protein in the blood called Vasn can help doctors better diagnose septic shock, a life-threatening infection complication. Researchers will compare Vasn levels in 144 ICU patients with septic shock to those with other types of shock. The goal is to fin…

This trial is testing if a needle-free device can collect cleaner blood samples for infection testing. When blood samples get contaminated by skin germs, it can lead to false alarms and unnecessary antibiotic use. The study will compare the new device against the standard needle …

This study aims to find the best way for hospitals to implement a proven infection prevention program. It will involve 6,000 patients having joint or spine surgery across many hospitals. The program combines several basic safety steps, like better hand hygiene and patient skin cl…

This study aims to make sure laboratory tests that measure how much of a drug is in a person's body are accurate and reliable. Researchers will collect samples of blood and other fluids from about 100 adults, some taking medications and some not, to test and validate the measurem…

This study tests whether educating doctors and healthcare teams about current guidelines can reduce unnecessary antibiotic use in intensive care units (ICUs). Researchers will work with 10 Brazilian ICUs, providing training and feedback on when to start antibiotics, when to stop …

This study aims to see if data from wearable devices, like smartwatches, can help detect infections earlier in children receiving cancer treatment. Researchers will collect heart rate, activity, and other health data from 150 children over four weeks to train a computer model. Th…

This study aims to understand if antibiotic-resistant bacteria are present in the gut of people taking medication to prevent HIV (PrEP). Researchers will analyze samples from 200 participants during their regular check-ups, looking for resistant bacteria. The goal is to gather in…

This long-running National Institutes of Health (NIH) study aims to better understand infectious and inflammatory diseases by evaluating patients with these conditions. It enrolls people aged 3 and older who have symptoms or a suspected exposure. The main goal is to gather medica…