MRNA 'Repair' for immune cells shows promise in rare infection disease
NCT ID NCT05189925
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 29 times
Summary
This early-stage study tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people unable to fight off infections. Researchers take a participant's own white blood cells, add a corrective mRNA instruction, and return the cells to the body. The goal is to temporarily restore the cells' ability to kill germs and see if the procedure is safe and feasible. The study involves 25 men aged 18-75 with a specific CGD mutation.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INFECTION are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.