MRNA therapy gives immune cells a temporary boost against rare infection disease
NCT ID NCT05189925
First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 5 times
Summary
This early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. The goal is to see if the procedure is safe and feasible, and whether it can temporarily restore the cells' ability to kill germs. The study involves 25 adult males and includes a hospital stay for cell collection and infusion.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mRNA-corrected white blood cells (gp91 Grans)
- What this could lead to
- If successful, this could provide a temporary way to restore infection-fighting ability in people with CGD, reducing infection risk.
- What could go wrong
- This is a very early Phase 1 trial with only 25 participants. The effect is temporary, and there may be side effects from the infusion or the cell collection process.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHRONIC GRANULOMATOUS DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Aging in place: could mobile teams keep nursing home residents out of the hospital?
- A pillow shaped to protect the spine after surgery — a small trial puts it to the test
- Drone Warfare's hidden toll: new study tracks infection risk in combat wounds
- Rapid molecular tests could help doctors prescribe antibiotics more precisely
- Newborn screening study aims to catch rare diseases at birth
- Do future doctors know the skin risks of tattoos and piercings?