Nutty idea: early tree nut exposure may shield Peanut-Allergic babies

NCT ID NCT04801823

Completed Prevention Sponsor: Murdoch Childrens Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving tree nuts early to infants with peanut allergy could prevent them from developing tree nut allergies. 212 babies aged 4-11 months were split into two groups: one had a supervised hospital challenge with four tree nuts followed by home introduction, the other followed standard care (home introduction only). The goal was to see which approach better reduced tree nut allergy by 18 months of age.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tree nuts (almond, cashew, hazelnut, walnut)
What this could lead to: If it works, this could show that early, supervised exposure to tree nuts prevents tree nut allergies in infants already allergic to peanuts.
What could go wrong: The trial is small (212 infants) and open-label, so results may be less reliable. Tree nut allergies are serious, and reactions during introduction are possible.

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Conditions

The condition(s) this trial relates to.

food allergy Nut Hypersensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOOD ALLERGY IN INFANTS NUT ALLERGY

Contacts and locations

Locations

Murdoch Children's Research Institute (MCRI)

Melbourne, Victoria, 3052, Australia

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