Can gentle oscillations help premature babies breathe better?

NCT ID NCT01277874

Terminated Disease control Sponsor: University of Utah Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether adding gentle oscillations to standard nasal continuous positive airway pressure (NCPAP) improves breathing support for newborns with respiratory distress syndrome. Premature infants who need NCPAP will be randomly assigned to receive either oscillatory NCPAP or standard NCPAP. Researchers will compare how well each method stabilizes breathing, reduces the need for mechanical ventilation, and shortens the time on respiratory support.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oscillatory nasal continuous airway pressure (Osc-NCPAP), a device that adds oscillations to standard NCPAP delivered via nasal prongs
What this could lead to: If oscillatory NCPAP works better than standard NCPAP, it could reduce the need for mechanical ventilation in premature infants and improve their breathing stability.
What could go wrong: This is an early-stage trial with a small number of participants, so results may not be conclusive. The added oscillations could also cause discomfort or other unforeseen issues in fragile newborns.

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Conditions

The condition(s) this trial relates to.

adult acute respiratory distress syndrome Premature Birth respiratory distress syndrome in premature infants

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREMATURITY RESPIRATORY DISTRESS SYNDROME

Contacts and locations

Locations

Primary Children's Medical Center

Salt Lake City, Utah, 84113, United States
University of Utah Health Sciences Center

Salt Lake City, Utah, 84132, United States
Valley Children's Healthcare

Madera, California, 93636, United States

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