PREMATURITY

This study is testing a combination treatment for very premature babies to see if it can safely reduce their need for blood transfusions and improve their iron levels and brain development. It will compare two forms of intravenous (IV) iron given with a drug called darbepoetin ag…

This study aims to find the best amount of human milk to feed very premature babies to help them grow well and keep their guts healthy. Researchers will compare two different feeding volumes (140-160 mL/kg/day vs. 180-200 mL/kg/day) in about 486 infants born between 27 and 31 wee…

This study is testing if adding a second antibiotic (azithromycin) to the standard treatment (ampicillin) leads to healthier babies when a pregnant person's water breaks too early, between 34 and 37 weeks. Researchers will compare the two treatments in about 311 participants to s…

This study is testing if delivering healthy groceries directly to the homes of pregnant women who struggle to afford food can improve their health and their babies' health. It will enroll 360 pregnant women in Ohio who are eligible for Medicaid. Researchers will compare different…

This study is testing whether playing specially designed music, sometimes with a parent's recorded voice, can help very premature babies in the hospital. Researchers want to see if this reduces the babies' stress, helps their brains develop better, and improves their language ski…

This study aims to understand if a mother's stress after a premature birth is linked to changes in her breast milk and her baby's brain development and feeding success. Researchers will follow 120 mothers and their preterm babies, collecting milk and stool samples to look for con…

This study aims to understand how certain fats (omega-3 fatty acids) and how the placenta processes them might be connected to an eye disease called retinopathy of prematurity (ROP) in very premature babies. Researchers will compare mothers who give birth very early (before 29 we…

This study aims to understand how changing the air flow rate in a non-invasive breathing machine affects carbon dioxide levels in premature infants. Researchers will observe 45 preterm babies, randomly switching between low and high flow settings while monitoring their breathing.…