Could a tiny tube spare preterm babies from breathing machines?
NCT ID NCT06421506
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests whether giving surfactant through a small tube while babies breathe with high-flow nasal cannula support can reduce the need for invasive ventilation. The study includes infants born 2-6 weeks early who have respiratory distress. Researchers will compare outcomes between those receiving this less invasive method and those who do not, looking at ventilation rates, hospital stay length, and lung function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Less invasive surfactant administration (LISA) during high-flow nasal cannula oxygen treatment
- What this could lead to
- If effective, this approach could reduce the need for invasive ventilation in late preterm and term infants with respiratory distress, potentially leading to shorter hospital stays and fewer complications.
- What could go wrong
- The trial is still in early stages, and results may not confirm benefit. The procedure carries risks such as discomfort or transient breathing changes, and its effectiveness may vary among infants.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
King's College Hospital
RECRUITINGLondon, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can gentle oscillations help premature babies breathe better?
- Can an Oxygen-Boosting drug help when all else fails?
- Can a steroid shot into the windpipe protect preemies' lungs?
- Experimental 'Storm Stopper' therapy tested for COVID-19, flu, and RSV
- Simple bedside ultrasound may spot lung risk in preemies
- Tiny lungs, big Tune-Up: can adjusting ventilator pressure help preterm babies?