Could a tiny tube spare preterm babies from breathing machines?

NCT ID NCT06421506

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether giving surfactant through a small tube while babies breathe with high-flow nasal cannula support can reduce the need for invasive ventilation. The study includes infants born 2-6 weeks early who have respiratory distress. Researchers will compare outcomes between those receiving this less invasive method and those who do not, looking at ventilation rates, hospital stay length, and lung function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Less invasive surfactant administration (LISA) during high-flow nasal cannula oxygen treatment
What this could lead to
If effective, this approach could reduce the need for invasive ventilation in late preterm and term infants with respiratory distress, potentially leading to shorter hospital stays and fewer complications.
What could go wrong
The trial is still in early stages, and results may not confirm benefit. The procedure carries risks such as discomfort or transient breathing changes, and its effectiveness may vary among infants.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • King's College Hospital

    RECRUITING

    London, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.