Lung transplant study tests whether ECMO should be used routinely or only when needed

NCT ID NCT06615492

Recruiting now Disease control Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to more days free from intensive care and fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Extracorporeal membrane oxygenation (ECMO) device
What this could lead to: If it works, this could show that using ECMO only when needed is safer and just as effective as using it routinely, potentially reducing complications like bleeding and infection.
What could go wrong: This is a single-center trial with 218 participants, so results may not apply to all hospitals. ECMO itself carries risks like bleeding and clotting, and the selective approach might not prevent severe complications in some patients.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset interstitial lung disease pulmonary fibrosis respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD (CHRONIC OBSTRUCTIVE PULMONARY DISEASE) INTERSTITIAL LUNG DISEASE (ILD) PULMONARY FIBROSIS RESPIRATORY FAILURE

Contacts and locations

Locations

Centre Hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X3E4, Canada
Univeristy of Alberta & Alberta Health Services
NOT_YET_RECRUITING

Edmonton, Alberta, T6G2G3, Canada
University Health Network / Toronto General Hospiatl
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1M1, Canada
Vancouver General Hospital
NOT_YET_RECRUITING

Vancouver, British Columbia, Canada

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