PULMONARY FIBROSIS

This study tests an inhaled version of the drug pirfenidone (AP01) in 375 adults with progressive pulmonary fibrosis, a condition where lung scarring worsens over time. Participants receive either a high dose, low dose, or placebo twice daily for 52 weeks, alongside their usual c…

This study looks at two ways of using a heart-lung machine (ECMO) during lung transplants: using it for every patient or only when needed. The goal is to find out which method leads to fewer complications and better recovery. About 218 adults getting a lung transplant will take p…

This study is testing a new imaging agent called [68Ga]Ga-NI-FAPI-04 for PET/CT scans to see if it can better detect diseases related to fibroblast activation protein, such as tumors, heart disease, lung fibrosis, and immune conditions. About 30 adults aged 18-85, including both …

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup (scarring) in the lungs of people with pulmonary fibrosis and lung cancer. Researchers will compare scans from healthy volunteers and patients to see if the age…

This study aims to find genetic traits that may explain why some people develop pulmonary fibrosis and why scarring patterns differ. Researchers will collect blood samples from 2,000 adults with confirmed pulmonary fibrosis to analyze specific gene variations. The goal is to bett…

This study is looking for early warning signs that lung scarring (fibrosis) is getting worse in people with various types of interstitial lung disease. Researchers will follow 450 adults over time, using blood tests, breathing tests, CT scans, and breath analysis to find markers …

This study is testing whether special PET and MRI scans can predict how quickly lung scarring (pulmonary fibrosis) will worsen in people with certain lung diseases. Researchers will follow 60 adults for up to 2 years to see if the scans can identify who will develop progressive f…

This study looks at whether people with pulmonary fibrosis can use home monitoring and video calls instead of half their regular clinic visits. The goal is to see if this helps patients manage their own health better. About 220 adults with pulmonary fibrosis will take part, and r…

This study is creating a registry and biobank for people with interstitial lung disease (ILD), including sarcoidosis, pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to better underst…

This early-stage study is testing a new drug called HRS-9813 in 20 healthy adults to see how it interacts with two existing medicines for pulmonary fibrosis (pirfenidone and nintedanib). The goal is to measure drug levels in the blood and check for side effects. This study does n…

This study collects lung tissue from patients undergoing lung transplant to investigate what causes pulmonary fibrosis at the cellular level. Researchers will examine cells and proteins from the donated lungs. The goal is to better understand the disease, not to test a new treatm…

This study looks at how immunosuppression treatment changes lung scarring in people with certain types of interstitial lung disease (not IPF). Researchers will use special PET and MRI scans to measure collagen buildup and tissue damage. The goal is to better understand the diseas…

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will analyze DNA from up to 3,500 people, including healthy volunteers, to find genetic differences linked to lung problems. A small optional part of the s…