PULMONARY FIBROSIS

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study looks for early signs of pulmonary hypertension (high blood pressure in the lungs) in people with chronic lung diseases like COPD or pulmonary fibrosis. Researchers will analyze collagen fragments in blood and lung tissue to create a 'fingerprint' that could lead to si…

This study tests a new radioactive dye called 68Ga-NI-FAPI for PET/CT scans. It aims to better detect diseases like tumors, heart problems, and lung scarring by targeting a protein linked to tissue damage. About 30 people, including healthy volunteers and patients, will take part…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This study tests a non-invasive imaging method called electrical impedance tomography (EIT) to monitor lung function in 400 adults with lung diseases like COPD, asthma, or pneumonia. Unlike standard spirometry, which requires active blowing, EIT works even in patients who cannot …

This study looks at whether an artificial intelligence (AI) tool can predict if lung scarring (pulmonary fibrosis) will get worse over time. Researchers will analyze CT scans from 200 people with either idiopathic pulmonary fibrosis (IPF) or other types of interstitial lung disea…

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will examine DNA from up to 3,500 people with and without lung disease to find genetic differences. The goal is to better understand what causes these cond…

This study is testing whether people with pulmonary fibrosis can safely replace half of their regular clinic visits with home monitoring. Participants will use a home spirometer, pulse oximeter, and a smartphone app to track their health and communicate with their care team. The …

This observational study aims to find early biomarkers that can predict if a person's lung scarring (pulmonary fibrosis) will get worse quickly. Researchers will follow 450 adults with various types of interstitial lung disease, including IPF and other fibrotic conditions. Partic…

This study looks at how immunosuppression treatment changes lung scarring in people with certain types of interstitial lung disease (not IPF). Using advanced PET and MRI scans, researchers will measure collagen buildup and tissue damage. The goal is to better understand the effec…

This early-stage trial is testing a new drug called HRS-9813 in 20 healthy volunteers to see how it interacts with two standard treatments for pulmonary fibrosis (lung scarring): pirfenidone and nintedanib. The goal is to measure drug levels in the blood and check for side effect…

This study tests whether special PET and MRI scans can predict how fast lung scarring (pulmonary fibrosis) will get worse in 60 adults aged 18-80 with certain types of this disease. Participants will have scans and breathing tests over 2 years. The goal is to see if these imaging…

This study collects lung tissue from patients awaiting a lung transplant to learn more about pulmonary fibrosis at the cellular level. Researchers will examine cells and proteins linked to the disease. About 90 participants will provide tissue samples, but no experimental treatme…

This study collects blood samples from 2,000 adults with pulmonary fibrosis to find genetic traits that may explain why they developed the disease and why scarring patterns differ. Participants must be 18 or older and have a confirmed diagnosis. The goal is to better understand t…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis, idiopathic pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to su…