Oxygen dilemma: which level saves preterm brains?
NCT ID NCT03825835
First seen Nov 20, 2025 · Last updated Jun 23, 2026 · Updated 25 times
Summary
This study compares using 30% versus 60% oxygen when resuscitating extremely preterm babies (born before 29 weeks). The goal is to see which oxygen level leads to better survival and fewer long-term developmental problems like cerebral palsy or vision/hearing loss. About 1,200 babies across multiple hospitals will take part, with each hospital switching between the two oxygen levels over time.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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BC Children
RECRUITINGVancouver, British Colubia, Canada
Contact Email: •••••@•••••
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CHEO
ACTIVE_NOT_RECRUITINGOttawa, Ontario, Canada
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Chu University Laval
RECRUITINGQuébec, Quebec, Canada
Contact Email: •••••@•••••
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Foothills Hospital
ACTIVE_NOT_RECRUITINGCalgary, Alberta, Canada
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Health Sciences
RECRUITINGWinnipeg, Manitoba, Canada
Contact Email: •••••@•••••
Contact
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Hospital Germans Tries i Pujol
WITHDRAWNBarcelona, Spain
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Hospital Las Palmas
WITHDRAWNLas Palmas de Gran Canaria, Spain
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Hospital Universitario Dexeus
WITHDRAWNBarcelona, Spain
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Hospital Universitario Materno Infantil Miguel Servet
WITHDRAWNZaragoza, Spain
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Hospital de Asturias
WITHDRAWNOviedo, Spain
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Hospital de la Arrixaca
WITHDRAWNEl Palmar, Spain
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Janeway Children's Health and Rehabilitation Centre
ACTIVE_NOT_RECRUITINGSt. John's, Newfoundland and Labrador, A1B 3V6, Canada
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McGill Univeristy
ACTIVE_NOT_RECRUITINGMontreal, Quebec, Canada
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Neonatal Intensive Care Unit - Hamilton Health Sciences
ACTIVE_NOT_RECRUITINGHamilton, Ontario, L8S 4K1, Canada
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Neonatal Intensive Care Unit - Mount Sinai Hospital
ACTIVE_NOT_RECRUITINGToronto, Ontario, Canada
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Newborn Health - IWK Health Centre
ACTIVE_NOT_RECRUITINGHalifax, Nova Scotia, Canada
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Queen's University
WITHDRAWNKingston, Ontario, K7L 3N6, Canada
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Royal Alexandra Hospital
ACTIVE_NOT_RECRUITINGEdmonton, Alberta, T5H 3V9, Canada
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Sunnybrook Health Sciences Centre
ACTIVE_NOT_RECRUITINGToronto, Ontario, Canada
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University College Cork
RECRUITINGCork, Ireland
Contact Email: •••••@•••••
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Université de Sherbrooke
RECRUITINGSherbrooke, Quebec, J1N 3C6, Canada
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
oxygen
What this could lead to
If it works, this could establish the safest oxygen level to use when resuscitating extremely preterm babies, potentially reducing death and long-term brain injury.
What could go wrong
This is a large trial but still testing a common practice; the difference between 30% and 60% oxygen may be small, and results may not apply to all hospitals or babies.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.