Can your genes predict how internship stress affects your mood?

NCT ID NCT01809080

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This study follows thousands of medical interns through their first year of residency—a time of intense, predictable stress—to see how genes and stress together might trigger depression. By tracking mood and genetic markers over 12 months, researchers hope to untangle why some people become depressed under pressure while others do not. The findings could shed light on the roots of depression and point toward who might need extra support.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify who is more vulnerable to stress-related depression, potentially leading to early interventions or preventive strategies.
What could go wrong: This is an observational study, so it cannot prove cause and effect. The findings may not apply beyond medical interns, and genetic associations may be weak or inconsistent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

University of Michigan Medical School

Ann Arbor, Michigan, 48109, United States

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