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MRI study reveals how neck position impacts brain fluid flow

NCT ID NCT00795080

Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses MRI scans to understand how different neck positions affect the flow of cerebrospinal fluid (the fluid around the brain and spine) in people with Chiari malformations and similar neck abnormalities. Researchers will compare fluid flow in healthy volunteers and patients, both before and after surgery in some cases. The goal is to learn more about the condition, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2012

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pilot group consisting of 10 healthy volunteers. Patients recruited w/incidental findings of Chiari 1 malformations and Patients recruited with known Chiari and other CVJ malformations (prior to surgery)

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers must be 18 yrs of age or older. * Patients w/Chiari 1 or CVJ malformations aged 12 yrs or older, * Able to cooperate in flexing and extending their neck within the cervical spine coil used for MR Imaging. * Pediatric patients will be included only if they can cooperate for additional sequences done for the study who don't require sedation or any form of anesthesia. Exclusion Criteria: * Patients who are medically unstable or cannot voluntarily flex or extend their necks. * Patients who have hardware in the head or necks which are incompatible with MR imaging. * Patient requiring any form of sedation which can lead to compromise of the airway with maneuvers described above. * History of prior head trauma or history of neurological conditions which can result in altered CSF dynamics.

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Conditions

The condition(s) this trial relates to.

Chiari malformation Chiari malformation type I

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chiari malformations

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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