BRONCHOPULMONARY DYSPLASIA

This study looks at whether different oxygen levels can help preterm infants who have both a chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in the lungs (pulmonary hypertension). About 39 infants born extremely early will be enrolled. Researchers will m…

This study compares two types of intravenous fat emulsions (mixed oil vs. soybean oil) in extremely premature infants (born before 28 weeks or weighing ≤1000g). The goal is to see which one better prevents a serious lung condition called bronchopulmonary dysplasia and supports no…

This study tests a medicine called IVIG (intravenous immunoglobulin) to see if it helps prevent or reduce lung disease in very premature babies born at 28 weeks or earlier. About 29 babies will receive IVIG for several days, and researchers will check their lung health and any si…

This study tests a new type of breathing support (NIV-NAVA) for very premature babies (born at 23-28 weeks) who are being taken off a ventilator. The goal is to see if this smarter support helps them breathe on their own without failing within 5 days, compared to standard support…

This study tests whether intravenous immunoglobulin (IVIG) can help premature babies with bronchopulmonary dysplasia (BPD), a serious lung condition. Twenty infants born between 25 and 30 weeks will receive IVIG infusions for 5 days. The goal is to see if this treatment helps the…

This study tests an investigational drug, zelpultide alfa, to see if it can prevent bronchopulmonary dysplasia (BPD)—a serious lung condition—in extremely premature babies (born at 22 to 27 weeks). About 366 babies on breathing machines will receive either the drug or a placebo a…

This study tests if giving less fluid (135 mL per kg per day) compared to standard fluid amounts (165 mL per kg per day) can prevent a serious lung condition called bronchopulmonary dysplasia (BPD) in very premature babies (born before 30 weeks). The trial will include 750 infant…

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is t…

This early-stage study tests the safety of an inhaled steroid (ciclesonide) in 30 premature babies who are on breathing machines and at risk for a chronic lung condition called bronchopulmonary dysplasia. Researchers will monitor side effects like high blood sugar, growth changes…

This study looks at how to set the breathing machine (ventilator) for preterm babies born before 34 weeks. The goal is to find the pressure that helps their lungs work best without hurting their heart. Researchers will use ultrasound and a special imaging tool to check heart func…

This study is testing a device called Electrical Impedance Tomography (EIT) that creates images of the lungs without using radiation. It will be used in children with chronic lung diseases, neuromuscular disorders, and healthy volunteers to see if it can provide useful informatio…

This study tests whether a special pressure-sensing mattress can accurately track breathing and heart rate in newborns who need breathing support. Researchers will compare the mattress readings to standard monitors in 60 infants. The goal is to see if this non-invasive method can…

This study looks at how doctors decide when to take extremely preterm babies (born before 28 weeks) off a breathing machine in their first two weeks of life. Researchers will ask doctors daily why they choose to remove the tube or keep it in, and then check if those decisions lea…

This study aims to measure lung function in premature infants with bronchopulmonary dysplasia (BPD) using a technique called forced oscillometry. Researchers will compare these measurements with those from healthy term infants. The study involves 80 infants and will also test how…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…

This study uses MRI scans to learn how the lungs grow and develop in premature babies, especially those with a breathing problem called BPD. Researchers will look at lung structure and function in about 160 infants during quiet breathing. The goal is to better understand prematur…