A new MRI test could spot a hidden Heart-Lung danger in babies
NCT ID NCT06440408
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This pilot study tests whether a special MRI technique can measure wall shear stress—the force of blood against vein walls—in the pulmonary veins of infants. These veins carry blood from the lungs to the heart, and narrowing them (pulmonary vein stenosis) is a life-threatening condition. The study includes infants with normal hearts and those with pulmonary vein stenosis, using ferumoxytol as a contrast agent to enhance the images. If successful, this approach could lead to better screening and treatment guidance for at-risk infants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ferumoxytol (contrast agent for cardiac MRI)
- What this could lead to
- If successful, this imaging technique could help identify infants at risk for pulmonary vein stenosis earlier and guide treatment decisions.
- What could go wrong
- This is a small pilot study with only 20 participants, so results may not apply broadly. The technique is experimental and may not reliably measure wall shear stress in all infants.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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