Gentler resuscitation may protect fragile lungs in tiniest babies
NCT ID NCT01223274
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care with 100% oxygen alone, while the other half get oxygen plus CPAP or PEEP through a facemask. The goal is to see if this gentler approach is feasible and reduces the need for breathing tubes and long-term ventilation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CPAP/PEEP (continuous positive airway pressure/positive end-expiratory pressure) via Neopuff device
What this could lead to
If this approach works, it could lead to better breathing support for the tiniest newborns, potentially reducing lung injury and the need for long-term ventilation.
What could go wrong
This is an early pilot study with only 104 infants, so results may not be conclusive. The intervention may not improve outcomes and could carry risks like lung overinflation or air leaks.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Case Western Reserve University, Rainbow Babies and Children's Hospital
Cleveland, Ohio, 44106, United States
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Cincinnati Children's Medical Center
Cincinnati, Ohio, 45267, United States
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RTI International
Durham, North Carolina, 27705, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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University of California at San Diego
San Diego, California, 92103-8774, United States
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University of Miami
Miami, Florida, 33136, United States