Bronchopulmonary dysplasia

This pilot trial tests whether feeding directly into the small intestine (transpyloric) is better than feeding into the stomach (gastric) for very preterm infants with bronchopulmonary dysplasia, a chronic lung condition. The study will measure how often babies have low oxygen le…

This study tests whether feeding preterm infants with chronic lung disease through a tube placed past the stomach (into the small intestine) helps their breathing more than feeding through a tube in the stomach. About 50 high-risk preterm babies born before 32 weeks will receive …

This trial tests whether a new breathing support method called NIV-NAVA helps very preterm infants (born at 23-28 weeks) avoid breathing failure after being taken off a ventilator. About 478 infants will be randomly assigned to receive either NIV-NAVA or standard non-synchronized…

This trial investigates whether giving very preterm infants (born at 24-29 weeks) a daily supplement of two fatty acids—ARA and DHA—starting within three days of birth can reduce their risk of bronchopulmonary dysplasia (BPD), a chronic lung disease common in premature babies. Ha…

This study tests whether different oxygen targets (higher vs. lower) improve outcomes in 39 preterm infants with bronchopulmonary dysplasia and pulmonary hypertension. Each infant will experience both oxygen levels in a crossover design. The goal is to see which level reduces dan…

This study tests montelukast, an asthma drug, in 28 premature infants at high risk for bronchopulmonary dysplasia (BPD), a serious lung condition. Researchers want to see if the drug is safe and how it moves through the body. The infants receive montelukast or a placebo daily for…

This phase 2 trial tests whether intravenous immunoglobulin (IVIG) can treat bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants. Twenty babies born between 25 and 30 weeks will receive IVIG infusions over five days. Researchers will check if the treatme…

This early-phase study tests whether an oral supplement called L-Citrulline is safe for preterm babies born at or before 30 weeks who have lung problems (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of a natural substance in the blood can reduce…

This study compares two types of fat infusions (mixed oil vs. soybean oil) given to extremely preterm infants to improve nutrition and reduce the risk of bronchopulmonary dysplasia (a chronic lung disease) and neurodevelopmental impairment. About 230 babies born before 28 weeks o…

This phase 2 trial tests whether intravenous immunoglobulin (IVIG) can help treat bronchopulmonary dysplasia (BPD), a serious lung condition, in premature infants born at 28 weeks or earlier. The study will give IVIG to 29 babies and track their breathing support needs and lung h…

This early-phase trial is testing whether metformin, a common diabetes drug, is safe for premature infants with or at risk of bronchopulmonary dysplasia (BPD), a chronic lung disease. The study involves 40 babies split into two groups: older infants already diagnosed with BPD and…

This study is for very premature babies (born between 24 and 29 weeks) to find the safest and most effective dose of a medicine called anakinra, which helps reduce inflammation. About 24 infants will receive anakinra through an IV or a shot under the skin. Researchers will measur…

This study tests whether using an air purifier at home can improve lung development in babies born prematurely (before 37 weeks). Researchers will measure indoor air quality and the babies' breathing at home, with and without the purifier. 180 infants up to age 6 are being recrui…

This study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…

This study tests whether a soft, FDA-approved belly band can help premature babies on breathing support develop stronger abdominal muscles. Researchers will measure muscle thickness with ultrasound and see if babies reach full oral feedings earlier. About 40 premature infants bet…

This study tests a remote monitoring system using pulse oximeters to optimize oxygen therapy in premature infants with bronchopulmonary dysplasia (BPD). Researchers aim to reduce the time babies need oxygen and prevent complications like pulmonary hypertension. The trial involves…

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is t…

This study tests an investigational drug called zelpultide alfa to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature babies (born between 22 and 27 weeks). About 366 high-risk infants will receive either the drug or a p…

This study tests if giving very premature babies (born before 30 weeks) slightly less fluid (135 mL per kg per day) compared to a standard amount (165 mL per kg per day) can prevent bronchopulmonary dysplasia (BPD), a chronic lung disease. About 750 babies will be enrolled across…

This early-stage study tests the safety of an inhaled steroid called ciclesonide in 30 premature babies who are on breathing machines and at risk for a chronic lung condition called bronchopulmonary dysplasia. Researchers will closely monitor side effects like high blood sugar, g…

This study compares severe respiratory infections in children with bronchopulmonary dysplasia (BPD) to those without BPD. Researchers will look back at past cases and follow new cases until 2030. The goal is to learn what makes these infections more dangerous for children with BP…

This study looks at whether a lung ultrasound score can help predict bronchopulmonary dysplasia (BPD), a serious lung condition, in premature babies born before 32 weeks. About 40% of extremely preterm infants develop BPD, which can cause long-term breathing problems. Researchers…

This study looks at how a pregnant woman's body handles caffeine and how much of it reaches her unborn baby. Researchers will give a small dose of caffeine to 30 women at risk of preterm delivery before a planned C-section. Blood samples from the mother, placenta, and newborn wil…

This study looks at whether a structured program can help more high-risk smokers get a first lung cancer screening with a CT scan. About 500 people aged 50 to 74 who smoke or recently quit will join. The goal is to see if a dedicated network makes screening easier and more effect…

This study tests a new discharge protocol for preterm infants with bronchopulmonary dysplasia (BPD), a chronic lung disease. The protocol was developed by national experts to improve the transition from NICU to home. Researchers will track follow-up rates, hospital readmissions, …

This study looks at how changing the pressure on a ventilator affects the lungs and heart of very premature babies (born before 34 weeks). Researchers will try different pressure levels and use ultrasound and imaging to see which setting works best for breathing and blood flow. T…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study observes how doctors decide when to remove breathing tubes (extubation) in extremely preterm infants born before 28 weeks. Researchers will track 100 babies in the NICU, asking doctors daily why they choose to extubate or not. The goal is to understand current practice…

This study is testing whether a pressure-sensing mattress can accurately monitor the breathing and heart rate of newborns who need breathing support. The mattress uses a technology called ballistocardiography to detect tiny movements. Researchers hope this could lead to a gentler…

This study looks at tiny particles called extracellular vesicles in the umbilical cord blood of extremely premature babies (born before 28 weeks). Researchers want to see if these particles can help predict serious problems like brain bleeding, lung injury, or death. The goal is …

This study uses a safe, radiation-free device called electrical impedance tomography (EIT) to take pictures of the lungs in infants, children, and young adults up to age 25. Researchers will compare images from patients with chronic lung or heart conditions to healthy controls to…

This study is looking at whether small differences in certain genes make very low birth-weight babies more likely to develop chronic lung disease and other complications of prematurity. Researchers will compare the genes of 1,100 infants who develop these conditions with those wh…

This study aims to measure lung function in premature infants with bronchopulmonary dysplasia (BPD) using a technique called forced oscillometry. Researchers will compare these measurements with those from healthy full-term infants. The goal is to better understand lung mechanics…

This study uses MRI scans to learn how lungs grow and develop in both full-term and extremely preterm babies, especially those with a breathing problem called bronchopulmonary dysplasia (BPD). Researchers want to better understand how prematurity affects lung structure and functi…

This study will use a special imaging technique called electrical impedance tomography (EIT) to see how lung volume changes in premature babies who are on a type of breathing support called synchronized noninvasive positive pressure ventilation (sNIPPV). Researchers want to under…

This study is recruiting 90 people aged 8-25 who are survivors of childhood leukemia, chronic lung disease of prematurity, or heart transplant, plus healthy controls. Researchers will use non-invasive exercise tests to measure heart and lung function during physical activity. The…

This study surveys 480 parents and caregivers of children under 18 who were born prematurely and developed bronchopulmonary dysplasia (BPD), a chronic lung condition. Researchers want to understand how BPD affects the family's quality of life, emotional well-being, and finances o…

This study is testing a device called Electrical Impedance Tomography (EIT) that uses electrodes to create images of the lungs without radiation. Researchers want to see if it can provide useful information about lung function in children with chronic respiratory diseases, includ…