Bronchopulmonary dysplasia

This Phase 3 trial tests whether adding budesonide (an anti-inflammatory) to standard surfactant treatment helps extremely preterm babies avoid chronic lung disease or death. About 642 infants born before 29 weeks or weighing under 1000 grams will receive either the combo or surf…

This study compares two ways of giving breathing support (PEEP) to very premature babies right after birth. One method uses a steady pressure, the other starts high then lowers it. The goal is to see which approach reduces the chance of death or chronic lung disease. Over 900 bab…

This study was designed to see if preterm children (born at or before 28 weeks) have differences in their retinal blood vessels compared to full-term children. Researchers planned to use a non-invasive imaging device called OCT angiography to measure blood vessel density. However…

This study looks at whether a simple bedside lung ultrasound can predict chronic lung disease in premature infants born before 32 weeks. Researchers will perform ultrasounds on 150 babies with breathing problems and track their outcomes. The goal is to see if early ultrasound sco…

This study follows 300 premature babies born before 33 weeks to see if the bacteria in their stool can predict life-threatening conditions like necrotizing enterocolitis, a severe gut infection. Researchers will also analyze the babies' DNA from saliva and look at small molecules…

This study follows 526 preterm infants born before 30 weeks who have a condition called patent ductus arteriosus (PDA), where a fetal blood vessel stays open too long. Researchers collect heart ultrasound, blood, and urine tests over the first month to predict which babies will c…

This study aimed to test a special MRI technique using hyperpolarized xenon gas to get detailed images of lung function in infants with bronchopulmonary dysplasia (BPD). The goal was to see if this method could reveal areas of poor ventilation or gas exchange without using radiat…

This study uses a non-invasive breathing test called forced oscillometry to measure lung function in 600 newborn infants, both full-term and premature, with and without lung conditions like respiratory distress or bronchopulmonary dysplasia. The goal is to better understand how t…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…