Which PEEP level saves preemie lungs? major trial seeks answer
NCT ID NCT04372953
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways of giving breathing support (PEEP) to very premature babies right after birth. One method uses a steady pressure, the other starts high then lowers it. The goal is to see which approach reduces the chance of death or chronic lung disease. Over 900 babies born between 23 and 28 weeks are taking part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Positive End-Expiratory Pressure (PEEP) via CPAP or ventilation
- What this could lead to
- If it works, this could identify the best way to support premature babies' breathing at birth, potentially reducing death or long-term lung disease.
- What could go wrong
- This is a large trial but still early-stage for clinical practice. The two PEEP strategies may show no clear difference, and results may not apply to all preterm infants.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Academic Teaching Hospital
Feldkirch, 6800, Austria
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Amalia Children's Hospital Radboudumc
Nijmegen, 6500, Netherlands
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Amsterdam University Medical Centre
Amsterdam, 1105, Netherlands
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Antoine Beclere Medical Center / South Paris University Hospitals
Paris, France
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Birmingham Heartlands Hospital
Birmingham, England, B9 5SS, United Kingdom
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Careggi Hospital
Florence, Italy
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Filippo del Ponte Hospital
Varese, Milan, 21100, Italy
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Gemelli University Hospital
Rome, Italy
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Indiana University / Riley Children Health at Indiana University Health
Indianapolis, Indiana, 46202, United States
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James Cook University Hospital
Middlesbrough, England, United Kingdom
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Joan Kirner Women & Children's Hospital - VIC
Melbourne, Victoria, 3021, Australia
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King Edward Memorial Hospital
Subiaco, Western Australia, 6008, Australia
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Mater Misericordiae
South Brisbane, Queensland, 4101, Australia
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Maxima Medical Centre
Veldhoven, 5504, Netherlands
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Ospedale Maggiore Policlinico
Milan, Italy
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Royal Hospital for Children
Glasgow, Scotland, United Kingdom
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Royal Infirmary Edinburgh
Edinburgh, Scotland, EH16 4SA, United Kingdom
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San Gerardo Hospital
Monza, Milan, 20090, Italy
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Sharp Mary Birch Hospital for Women & Newborns
San Diego, California, 92123, United States
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Southmead Hospital
Bristol, England, United Kingdom
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The Royal Women's Hospital, Melbourne Australia
Parkville, Victoria, 3052, Australia
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University Hospital Wishaw
Wishaw, Scotland, United Kingdom
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University Hospitals Leicester
Leicester, United Kingdom
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
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Vittore Buzzi Children's Hospital / Ospedale dei Bambini
Milan, Italy
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Women & Childrens Hospital Adelaide
Adelaide, South Australia, Australia
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