Immune clues in pregnancy: a new test for preterm birth risk?

NCT ID NCT05246579

Recruiting now Knowledge-focused Sponsor: John O'Brien, MD Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study is looking at whether certain immune-related substances in the blood and cervical fluid of pregnant women can help predict the risk of preterm birth. Researchers will compare these markers in women at high risk (due to a previous preterm birth, a short cervix, or symptoms) with those at low risk. The goal is to better understand the biological pathways that lead to early labor and potentially improve early detection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better ways to identify women at risk for preterm birth and potentially guide preventive treatments.
What could go wrong: This is an observational study, so it cannot prove cause and effect. The findings may not apply to all pregnant women, and the markers studied may not reliably predict preterm birth.

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Conditions

The condition(s) this trial relates to.

Inflammation Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVIX; PREGNANCY PRETERM BIRTH

Contacts and locations

Locations

University of Kentucky
RECRUITING

Lexington, Kentucky, 40506, United States

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