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Gum inflammation in pregnancy linked to preterm birth risk?

NCT ID NCT07699978

Knowledge-focused Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

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The trial has finished. Results may not be published yet.
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Cancelled before anyone took part.

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When the status isn't known

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Status unknown
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First seen Jul 13, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This study looks at whether inflammation from gum disease during pregnancy can affect the womb environment and lead to early delivery. Researchers will measure markers of inflammation and oxidative stress in saliva and amniotic fluid from 80 healthy pregnant women. The goal is to better understand the biological connection between oral health and pregnancy outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If links are found, this could point toward using simple saliva tests to identify pregnant women at risk for preterm birth.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not lead to any practical screening tool.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of pregnant women aged 18-40 years with singleton pregnancies between 28 and 32 weeks of gestation who receive routine prenatal care at the Department of Obstetrics and Gynecology, Gülhane Training and Research Hospital. Participants will undergo periodontal examination and will be categorized according to periodontal status (with or without periodontitis) and pregnancy outcome (term or preterm delivery).

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pregnant women between 28 and 32 weeks of gestation * Age 18 to 40 years * Singleton pregnancy * Systemically healthy * Normal gestational diabetes screening (oral glucose tolerance test within the hospital reference range) * Receiving only routine prenatal vitamin and iron supplementation (no therapeutic medications) * Low-risk pregnancy * No history of chorioamnionitis * No periodontal treatment within the previous 6 months * Able and willing to provide written informed consent Exclusion Criteria: * Multiple pregnancy * Use of antibiotics or anti-inflammatory medications during pregnancy * Current smoking or alcohol consumption * Presence of an acute infection * Placental pathology * Major fetal anomaly * High-risk pregnancy as determined by the obstetrician * Refusal or inability to provide informed consent

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Conditions

The condition(s) this trial relates to.

Inflammation periodontal disorder periodontitis Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease Pregnancy Preterm birth

How to take part

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  1. The official record

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