Cure My Disease

Don't miss your cure!

 Log in / Sign up

Citrulline: a potential key to prolonging pregnancy in pre-eclampsia?

NCT ID NCT02801695

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Pre-eclampsia is a serious pregnancy complication that can harm both mother and baby, and the only cure is delivering the baby. Researchers are testing whether citrulline, a natural amino acid, can safely prolong pregnancy for women hospitalized with pre-eclampsia before 36 weeks. In this trial, 116 women will receive either citrulline or a placebo to see if citrulline delays the need for delivery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
citrulline, an amino acid supplement
What this could lead to
If citrulline works, it could give doctors a way to safely prolong pregnancy in pre-eclampsia, reducing risks for babies born too early.
What could go wrong
This is a mid-stage trial with 116 women, so results may not hold in larger groups. Citrulline might not delay delivery, and pre-eclampsia can worsen quickly, requiring immediate delivery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

116 people

The number who actually took part.

Started

Feb 2017

Finished

Dec 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age \>= 18 years old * pregnant woman * singleton pregnancy * woman with pre-eclampsia (\<36 weeks) without indication of forthcoming extraction * subjects affiliated with an appropriate social security system * subjects out of context of guardianship * written signed informed consent form Exclusion Criteria: * age \< 18 years old * isolated hypertension or isolated proteinuria * severe pre-eclampsia with indication of forthcoming extraction in emergency * term pregnancy \>= 36 Weeks when diagnosis is done * multiple pregnancy * lactose intolerance * context of guardianship

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Pre-eclampsia are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

preeclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pre-eclampsia Pregnancy

Contacts and locations

Locations

  • CHU de Nantes

    Nantes, 44093, France

  • Hôpital Cochin (Maternité Port-Royal)

    Paris, 75014, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.