Bronchopulmonary dysplasia

This study tests whether adding DHA/ARA supplements to the milk of extremely premature babies (born at 28 weeks or earlier) during their first two weeks of life can reduce the severity of bronchopulmonary dysplasia, a chronic lung disease. About 150 babies will be randomly assign…

This study tests whether using cord blood, rich in fetal hemoglobin, for transfusions in preterm infants can reduce serious complications like blindness, lung disease, and gut problems. Researchers will compare outcomes in 200 very low birth weight babies who receive either cord …

This study tests whether keeping very preterm babies on CPAP (a breathing machine) until 34 weeks after conception, instead of switching to a nasal cannula, reduces their risk of bronchopulmonary dysplasia (a chronic lung disease) or death. About 860 infants born before 29 weeks …

This study compares transfusions using red blood cells from umbilical cord blood versus standard adult donor blood in extremely premature infants. About 176 babies born before 28 weeks or weighing under 1000 grams will be enrolled. The goal is to see if cord blood reduces the ris…

This study tests whether giving the steroid betamethasone to extremely premature babies (born before 28 weeks) helps them come off breathing machines more easily and lowers their risk of chronic lung disease. About 100 babies will receive either standard NICU care plus betamethas…

This study tests whether a new breathing support called Pressure Targeted High Flow works as well as standard CPAP in premature infants with breathing problems. About 78 babies born before 33 weeks will try each method for 24 hours. Researchers will monitor breathing, oxygen need…

This study compares two types of high-frequency ventilators for premature babies born before 32 weeks who have breathing problems. The new mode, HFOV-VG, aims to deliver more stable breaths to reduce lung injury. Researchers will see if it lowers the chance of severe chronic lung…

This study tests whether giving a special lung medicine (surfactant mixed with budesonide) to extremely premature babies who are still on a breathing machine at 7-14 days old is safe and can help prevent a serious lung condition called bronchopulmonary dysplasia. About 24 babies …

This study tests two different ways of giving the steroid dexamethasone to very premature babies (born before 30 weeks) who have been on a breathing machine for at least two weeks. The goal is to see which treatment better prevents a serious lung condition called bronchopulmonary…

This study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …

This study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.

This pilot study tests whether a pre-visit questionnaire helps Black parents of preterm infants with chronic lung disease set and achieve health goals during primary care visits. Thirty parents will complete the questionnaire before a well-child visit and then report back on goal…

This observational study will look at how often very low birth weight babies in Canadian NICUs get ventilator-associated pneumonia (VAP) and how these infections are treated. Researchers will compare different hospitals' approaches to diagnosis and care, with the goal of creating…

This study uses a special eye scan (OCT angiography) to look at blood vessel development in the retinas of children born very prematurely (at or before 28 weeks) compared to those born full-term. The goal is to see if premature birth and related lung problems affect eye blood ves…

This study looks at whether artificial intelligence (AI) tools like ChatGPT, Gemini, and Claude can predict bronchopulmonary dysplasia (a serious lung condition) in premature babies. Researchers will use medical records from the first three weeks of life for 108 infants born befo…

This study looks at 40 premature babies (born before 30 weeks) to see if viruses in their lungs and gut during the first three weeks of life are linked to a serious lung condition called bronchopulmonary dysplasia (BPD). Researchers will collect throat and stool samples to track …

This study follows 270 preterm babies (born before 32 weeks) from birth to age 3. Researchers will regularly swab their noses to analyze the bacteria and other microbes living there. The goal is to see if the nose microbiome can predict which babies will develop bronchopulmonary …

This study tests a more sensitive ultrasound method called speckle tracking echocardiography (STE) to check heart function in newborns. Researchers will scan healthy babies and those with conditions like lung disease or oxygen deprivation to establish normal values and track chan…