Bronchopulmonary dysplasia

This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care…

This study tested whether giving very low birth weight preterm infants (born at or before 32 weeks, weighing under 1250 grams) a weekly high-dose oral vitamin A supplement could reduce their risk of developing bronchopulmonary dysplasia (BPD), a chronic lung disease. The trial ra…

This study tested whether sildenafil, a drug used for high blood pressure in the lungs, is safe for premature infants at risk of bronchopulmonary dysplasia (BPD), a serious chronic lung disease. 109 babies born before 29 weeks and needing breathing support were given either silde…

This study tested whether adding a cream made from human milk to the standard feeding of extremely premature babies (birth weight 500-1250 grams) could help them leave the hospital earlier. 210 infants were randomly assigned to get either the cream supplement or standard care. Th…

This study looked at whether the drug sildenafil is safe for premature infants with a severe lung condition called bronchopulmonary dysplasia (BPD). The study included 125 babies in hospital intensive care units. Researchers monitored for dangerously low blood pressure as the mai…

This study looked at whether using tiny blood samples instead of standard amounts can improve health in extremely preterm babies (born before 27 weeks). The goal was to see if this "less is more" approach reduces lung disease and other serious complications. Over 200 babies took …

This study looked at whether giving more red blood cell transfusions (liberal strategy) to extremely low birth weight babies (under 1000 grams) helps them survive without brain damage compared to a more restrictive approach. Over 1800 infants from NICUs were followed until 22-26 …

This early-stage trial tested a new drug called rfhSP-D in 18 premature babies born before 30 weeks. The goal was to find the safest dose that might prevent chronic lung disease, a common complication in preemies. The drug was given along with standard care to babies on breathing…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study looked at 60 premature newborns (born between 28-37 weeks) in the neonatal intensive care unit who had breathing problems or were on a ventilator. Researchers compared different chest physiotherapy methods and positions to see which worked best for clearing the lungs. …

This study examined whether a marker of cellular aging called p16Ink4a is linked to bronchopulmonary dysplasia (BPD), a serious lung disease in premature babies. Researchers measured p16 levels in blood from 80 newborns and children, comparing those with and without BPD. The goal…

This study looked at 136 premature babies who needed breathing help. Researchers tracked how long they needed support and checked for lung problems. The goal was to learn more about different non-invasive breathing methods, not to test a new treatment.

This study examined how indoor air quality impacts breathing symptoms and lung function in 165 school-aged children (6-12 years old) who were born prematurely and have bronchopulmonary dysplasia (BPD), a chronic lung disease. Researchers measured respiratory symptoms and lung fun…

This completed study looked at 322 premature babies born before 32 weeks to compare different ways of diagnosing bronchopulmonary dysplasia (BPD), a common lung disease. Researchers proposed a new classification that separates high-flow nasal cannula from other breathing support.…

This study looked at 541 premature babies with a heart condition called patent ductus arteriosus (PDA). Half received ibuprofen to close the vessel, while the other half got only supportive care like fluids or diuretics. Researchers compared closure rates and complications to see…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study looked at whether feeding very low birth weight premature infants directly into the duodenum (the first part of the small intestine) is safe and doable. The goal is to reduce stomach reflux that can worsen lung damage. Twenty-four infants were randomly assigned to rece…

This study looked at a new method to find out if diuretics (water pills) help individual premature babies with a chronic lung condition called bronchopulmonary dysplasia (BPD). Researchers enrolled 19 very premature infants and used a special 'N-of-1' approach, where each baby wa…

This study looked at 70 premature babies in the NICU to see if levels of certain proteins called neurotrophins in their blood could predict later lung and brain development. Researchers measured these proteins, which help nerves grow and lungs work properly, and tracked the babie…

This study tested whether a non-invasive imaging method called electrical impedance tomography (EIT) can predict when very preterm infants (born at 25-29 weeks) are ready to stop breathing support. Researchers placed EIT belts on 20 infants in the NICU to measure lung function. T…

This study follows 355 teenagers who were born very prematurely (26–32 weeks) in 1997 in France. Researchers measure their lung function and breathing symptoms to see how preterm birth affects respiratory health later in life. It is an observational study, meaning no treatment is…