Study questions routine ibuprofen for preemie heart condition

NCT ID NCT07533721

Completed Knowledge-focused Sponsor: Shengjing Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 541 premature babies with a heart condition called patent ductus arteriosus (PDA). Half received ibuprofen to close the vessel, while the other half got only supportive care like fluids or diuretics. Researchers compared closure rates and complications to see which approach works better for different gestational ages.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ibuprofen
What this could lead to: If successful, this could help doctors decide whether to use ibuprofen or simply monitor premature babies with a common heart condition, potentially reducing unnecessary drug exposure.
What could go wrong: This is a retrospective study, not a randomized trial, so results may be influenced by unmeasured factors. The findings may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bronchopulmonary dysplasia patent ductus arteriosus Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFANT, PREMATURE PATENT DUCTUS ARTERIOSUS

Contacts and locations

Locations

Shengjing Hospital of China Medical University

Shenyang, Liaoning, 110004, China

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