New feeding method aims to protect premature Babies' lungs

NCT ID NCT04246333

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether feeding very low birth weight premature infants directly into the duodenum (the first part of the small intestine) is safe and doable. The goal is to reduce stomach reflux that can worsen lung damage. Twenty-four infants were randomly assigned to receive either standard stomach feeds or duodenal feeds. The researchers measured how often the feeding tube was placed correctly and checked for complications like intestinal perforation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Duodenal feeding (feeding tube placed in the duodenum)
What this could lead to
If successful, this approach could offer a safer way to feed very premature infants, potentially reducing lung damage from reflux.
What could go wrong
This is a small, early feasibility study with only 24 infants, so results may not apply broadly. There is a risk of intestinal perforation from tube placement.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida, 33701, United States

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