Tiny lungs, big questions: can we tell which preemies benefit from water pills?

NCT ID NCT05898022

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looked at a new method to find out if diuretics (water pills) help individual premature babies with a chronic lung condition called bronchopulmonary dysplasia (BPD). Researchers enrolled 19 very premature infants and used a special 'N-of-1' approach, where each baby was switched between the drug and a placebo to see if they truly responded. The goal was to gather information to design a larger study, not to prove the drug works long-term.

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Conditions

The condition(s) this trial relates to.

bronchopulmonary dysplasia disease lung disorder Lung Injury respiratory system disorder Ventilator-Induced Lung Injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Case Western Reserve University, Rainbow Babies and Children's Hospital

    Cleveland, Ohio, 44106, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Emory University

    Atlanta, Georgia, 30303, United States

  • RTI International

    Durham, North Carolina, 27705, United States