Could a common heart drug protect Preemies' lungs?
NCT ID NCT03142568
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether sildenafil, a drug used for high blood pressure in the lungs, is safe for premature infants at risk of bronchopulmonary dysplasia (BPD), a serious chronic lung disease. 109 babies born before 29 weeks and needing breathing support were given either sildenafil or a placebo. Researchers tracked side effects and measured how the drug moved through the body to see if it might help prevent lung damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sildenafil (also known as Revatio)
What this could lead to
If sildenafil is found safe and effective, it could offer a new way to prevent or reduce lung damage in premature babies, potentially lowering the risk of bronchopulmonary dysplasia.
What could go wrong
This is an early Phase 2 safety study with only 109 infants, so results are preliminary. Sildenafil may not prove effective in larger trials, and side effects like retinopathy of prematurity remain a concern.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital of Nevada at UMC
Las Vegas, Nevada, 89106, United States
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Cohen Children's Medical Center of NY
New Hyde Park, New York, 11040, United States
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Golisano Children's Hospital - University of Rochester Medical Center
Rochester, New York, 14642, United States
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Health Sciences Centre Hospital
Winnipeg, Manitoba, R3A 1R9, Canada
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Monmouth Medical Center
Long Branch, New Jersey, 07740, United States
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Ochsner Baptist Medical Center
New Orleans, Louisiana, 70115, United States
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
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University of Florida College of Medicine Jacksonville-Wolfson Children's Hospital
Jacksonville, Florida, 32209, United States
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University of Florida Jacksonville Shands Medical Center
Jacksonville, Florida, 32209, United States
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University of Illinois at Chicago
Chicago, Illinois, 60612, United States
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University of Kentucky
Lexington, Kentucky, 40356, United States
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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University of Oklahoma
Oklahoma City, Oklahoma, 73104, United States
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WakeMed Health and Hospitals
Raleigh, North Carolina, 27610, United States
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Wesley Medical Center
Wichita, Kansas, 67214, United States