Feeding into the small intestine may reduce reflux and oxygen dips in fragile preterm infants

NCT ID NCT06534359

Recruiting now Disease control Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This pilot trial tests whether feeding directly into the small intestine (transpyloric) is better than feeding into the stomach (gastric) for very preterm infants with bronchopulmonary dysplasia, a chronic lung condition. The study will measure how often babies have low oxygen levels and serious side effects, and whether the feeding method reduces acid reflux. Sixty infants born before 32 weeks will be randomly assigned to one of the two feeding methods for two weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transpyloric tube feeding (feeding into the small intestine) and gastric tube feeding (feeding into the stomach)
What this could lead to: If transpyloric feeding works better, it could offer a safer way to feed very preterm infants with lung disease, reducing reflux and dangerous drops in oxygen levels.
What could go wrong: This is a small pilot study with only 60 infants, so results may not apply to all babies. The feeding tube into the small intestine may cause its own complications, and the trial is not designed to prove long-term benefits.

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Conditions

The condition(s) this trial relates to.

bronchopulmonary dysplasia gastroesophageal reflux disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHOPULMONARY DYSPLASIA GASTROESOPHAGEAL REFLUX

Contacts and locations

Locations

Children's Hospital Colorado
RECRUITING

Denver, Colorado, 80218, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Mercy Hospital
NOT_YET_RECRUITING

Kansas City, Missouri, 64108, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States

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