Can a gentle eye scan replace stressful exams for preterm infants?

NCT ID NCT07738874

First seen Jul 31, 2026 ยท Last updated Jul 31, 2026

Summary

This study tests whether a handheld, ultra-widefield eye scanner (OCT) can accurately identify preterm infants with severe retinopathy of prematurity (ROP), a condition that can harm vision. The scanner takes detailed images of the retina without touching the eye, potentially reducing stress compared to standard exams. Researchers will compare the scanner's accuracy against traditional methods and also measure infant stress during imaging. The goal is to develop a more objective, low-stress screening tool to improve early detection and treatment.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Ultra-widefield optical coherence tomography (OCT) imaging and wide-field fundus imaging
What this could lead to
If successful, this could lead to a gentler, more accurate way to screen preterm infants for severe ROP, potentially preventing vision loss.
What could go wrong
The imaging may not be as accurate as standard exams, and the stress of imaging could affect infants. Results are early and need validation.

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Conditions

The condition(s) this trial relates to.

eye disorder Infant, Newborn, Diseases Infant, Premature, Diseases Obstetric Labor Complications Obstetric Labor, Premature pregnancy disorder Premature Birth retinal disorder retinopathy of prematurity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Duke University Eye Center

    Durham, North Carolina, 27705, United States

  • University of Pennsylvania, Center for Preventive Ophthalmology and Biostatistics

    Philadelphia, Pennsylvania, 19104, United States

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