Can a single eye injection save sight in premature infants?

NCT ID NCT07721298

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial investigates whether an injection of ranibizumab, a drug that blocks abnormal blood vessel growth, can effectively treat aggressive posterior retinopathy of prematurity (AP-ROP) in premature infants. AP-ROP is a fast-progressing eye condition that can lead to retinal detachment and permanent blindness if not treated quickly. The study will measure how well the disease responds to the injection, how often it comes back, and whether additional injections are needed, with the goal of improving treatment strategies for these vulnerable babies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an anti-VEGF drug called ranibizumab, injected into the eye
What this could lead to
If it works, this could offer a vision-saving treatment for premature infants with a severe form of eye disease, potentially avoiding blindness.
What could go wrong
This is a small, early-stage trial with 39 infants, and the treatment may not work for all or could cause side effects like eye infection or disease recurrence.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ainshams University

    Cairo, Egypt

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Other studies related to the condition(s) this trial covers.