Gene test could personalize stroke prevention
NCT ID NCT05763862
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This study looks at whether genetic testing can help doctors pick the right antiplatelet medicine for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, is likely to work for them. If the test shows the drug may not be effective, patients will receive alternative medications. The goal is to see if this personalized approach reduces the chance of another stroke or heart problem over the next year.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- genetic testing for CYP2C19 mutations
- What this could lead to
- If successful, this could show that tailoring antiplatelet drugs based on genetics reduces the risk of another stroke or heart attack.
- What could go wrong
- This is a relatively small, early-stage feasibility study, and the benefit of genetic testing over standard care is not yet proven. Bleeding risks from alternative antiplatelet drugs also remain a concern.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Singapore General Hospital
Singapore, Singapore
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Other studies related to the condition(s) this trial covers.
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