Gene test could personalize stroke prevention
NCT ID NCT05763862
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether genetic testing can help doctors pick the right antiplatelet medicine for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, is likely to work for them. If the test shows the drug may not be effective, patients will receive alternative medications. The goal is to see if this personalized approach reduces the chance of another stroke or heart problem over the next year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
genetic testing for CYP2C19 mutations
What this could lead to
If successful, this could show that tailoring antiplatelet drugs based on genetics reduces the risk of another stroke or heart attack.
What could go wrong
This is a relatively small, early-stage feasibility study, and the benefit of genetic testing over standard care is not yet proven. Bleeding risks from alternative antiplatelet drugs also remain a concern.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Singapore General Hospital
Singapore, Singapore