Can an antidepressant stop migraines before they start?
NCT ID NCT07385755
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether desvenlafaxine, a drug typically used for depression, can help prevent migraines in adults who have frequent attacks. Researchers will compare the drug to a placebo in 440 participants over 12 weeks. The goal is to see if it reduces the number of migraine days per month.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Desvenlafaxine
What this could lead to
If it works, this could provide a new option for preventing frequent migraines, reducing the number of headache days per month.
What could go wrong
This is a mid-stage trial with no phase designation, so results are not yet confirmed. Desvenlafaxine may cause side effects like nausea or dizziness, and it might not work better than a placebo.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430000, China