Tongji Hospital

This study tests if a 300mg dose of secukinumab is safe and effective for Chinese adults with active ankylosing spondylitis (AS), a type of arthritis that causes back pain and stiffness. Participants must have tried at least two NSAIDs without success and never used biologic drug…

This study looks at how well a medicine called glycerol phenylbutyrate works for children with urea cycle disorders, a rare condition that causes dangerous ammonia buildup in the blood. About 40 children aged 0-18 in China will take the medicine and be followed for up to 5 years.…

This study compares a newer drug, telitacicept, to the standard treatment cyclophosphamide for lung scarring (interstitial lung disease) caused by lupus. About 100 adults with early lupus and mild-to-moderate lung involvement will receive one of the two drugs for a year. The goal…

This early-phase study tests a new CAR-T cell treatment called CT1190B for people with B-cell non-Hodgkin lymphoma that has come back or not responded to standard therapy. The main goals are to find a safe dose and see how well the treatment works. About 27 adults aged 18-75 will…

This early-stage study tests a modified virus (KD01) designed to infect and kill cancer cells in women with cervical or endometrial cancer. Phase I includes patients who have exhausted other treatments; Phase II focuses on younger women who wish to preserve fertility. The goal is…

This study tests a combination of two drugs—tislelizumab (an immunotherapy) and huaier granule (a traditional Chinese medicine)—as the first treatment for people with liver cancer that cannot be removed by surgery. About 94 adults with advanced liver cancer will receive this comb…

This study looks at whether adding a procedure to destroy lymphoid tissue in the back of the nose during standard sinus surgery can better control inflammation and reduce the return of nasal polyps. About 32 adults with chronic sinusitis and nasal polyps will be randomly assigned…

This study is tracking how well different monoclonal antibody treatments work for people with a rare autoimmune disease called neuromyelitis optica spectrum disorder (NMOSD). The disease causes the immune system to attack the nerves in the eyes and spine. The study will follow 20…

This study tests a new way to treat a type of brain bleed (intracerebral hemorrhage) using a small tube placed into the clot through a tiny hole in the skull. A clot-busting drug called tenecteplase is then injected to dissolve the clot. The goal is to see if this approach helps …

This study tests a new combination of four drugs (methotrexate, rituximab, sintilimab, and pirtobrutinib) in people newly diagnosed with primary central nervous system lymphoma (PCNSL), a rare type of brain cancer. The goal is to see if this combo works better than standard treat…

This early-phase study tests a new treatment called AZD0120 (GC012F) in 12 adults with end-stage kidney disease who are highly sensitized—meaning their immune system is likely to reject a donated kidney. The treatment uses specially engineered immune cells (CAR-T cells) to target…

This study tests a new mix of four drugs for people with advanced bile duct cancer that cannot be removed by surgery. The treatment combines two standard chemotherapy drugs (gemcitabine and cisplatin) with an immunotherapy (adebrelimab) and a common cholesterol-lowering drug (sim…

This study looks at whether a special high-MCT formula given before and after Kasai surgery can help infants with biliary atresia grow better. About 120 infants under 3 months old will take part. The formula is designed to be easier for the damaged liver to process and may improv…

This early-stage study tests a single injection of a gene therapy called V001-BCMA for people with autoimmune diseases like lupus that keep coming back or don't respond to standard treatments. The therapy targets a protein on certain immune cells to try to control the overactive …

This early-stage study tests a new cell therapy called QH103 in 6 people with severe autoimmune diseases like multiple sclerosis and myasthenia gravis that haven't responded to standard treatments. The therapy uses specially engineered immune cells to target and calm the overacti…

This study is for people with early-stage liver cancer who are scheduled for surgery. Researchers are testing whether an artificial intelligence (AI) tool can predict each person's risk of the cancer returning. For those at high risk, the study offers a personalized treatment pla…

This study tests whether a newer sedative called ciprofol can reduce heart damage after lung surgery compared to the standard drug propofol. About 1,058 adults aged 45–80 having keyhole lung surgery will be randomly assigned to receive one of the two drugs. The main goal is to se…

This study compares two versions of Angong Niuhuang Pills, a traditional Chinese medicine, in 100 adults who recently had an acute ischemic stroke. Participants will take the pills or receive standard care, and researchers will track recovery, brain imaging, and blood markers ove…

This early-stage study tests a new treatment called KD01, a modified virus that targets and kills bladder cancer cells. It is given directly into the bladder through a catheter. The study includes 29 people with different stages of bladder cancer, including those who did not resp…

This early-stage trial tests a new treatment called NouvSoma001 for people with neuromyelitis optica spectrum disorder (NMOSD), a rare disease that attacks the nerves in the eyes and spinal cord. The treatment uses tiny particles from stem cells, injected into the spine, to try t…

This study is testing a new blood test that looks for tiny molecules called MicroRNA in people with breast cancer. The goal is to see if this test can accurately detect the disease. Researchers will compare results from 100 participants, including healthy volunteers, to measure h…

This study aims to create an AI model that can accurately diagnose brain diseases like tumors, stroke, and infections from MRI scans. Researchers will use data from 1,000 patients to train and test the AI, comparing its performance to doctors. The goal is to improve diagnostic ac…

This study tests whether getting a flu vaccine can prevent serious heart problems in people who have recently had a heart attack or unstable angina. About 6,620 adults aged 18 to 80 will receive either the flu shot or a placebo and be followed for one year. Researchers will track…

This study looks at whether acupuncture can improve bowel movements in people with long-term constipation. 72 adults will receive either manual acupuncture or electroacupuncture three times a week for 12 weeks. The main goal is to see if participants have at least three complete …

This study tests two different sleep medicines (remimazolam and ciprofol) in children aged 2-12 having their tonsils removed. The goal is to see which one causes fewer breathing issues like coughing, airway blockages, or low oxygen during and right after surgery. About 114 childr…

This study looks at whether adding a nerve block to ease pain can help standard cancer drugs work better for people with advanced bile duct or pancreatic cancer. About 103 participants will get the pain-relief procedure and then start their regular cancer treatment. Researchers w…

This study tests whether combining a painkiller called tegileridine with a nerve block can better control pain after lung surgery. About 118 adults having lung surgery will receive this combination. The goal is to reduce pain, speed recovery, and possibly lower the risk of long-t…

This study tests a computer model that uses CT scans, tissue images, and patient data to predict if colon cancer will spread to the liver within two years after surgery. Researchers will enroll 160 patients with stage I-III colorectal cancer who are having curative surgery. No ex…

This study tests a computer model that uses patient data and scans to predict if early-stage liver cancer will come back within 2 years after surgery. About 353 adults with liver cancer will join, and their health will be tracked for 2 years. The goal is to see if the AI can accu…

This study is gathering information from 50,000 people with headaches to create a better system for diagnosing and treating them. Researchers will collect medical history, treatment data, and biological samples to understand different headache types. The goal is to help doctors m…

This study looks at how a common bowel-cleansing laxative (PEG) changes the gut microbiome in people who have had their gallbladder removed compared to those with a gallbladder. About 20 adults will provide stool samples before and up to 6 months after colonoscopy. The goal is to…

This study explores whether a new type of MRI can accurately measure fatty liver disease without needing a needle biopsy. Researchers will scan 500 people with metabolic-associated fatty liver disease and compare the MRI results to standard tests. The goal is to find a safer, non…

This study looks at data from 1,500 colorectal cancer patients who had surgery to remove their tumors. Researchers are building an AI model that uses CT scans, tissue images, and medical records to predict if the cancer will spread to the liver within 3 years. The goal is to crea…

This study looks at whether giving a nerve block (paravertebral block) during chest surgery can help prevent problems like lung infections, trouble breathing, or fluid buildup. Researchers will track 500 adults having keyhole or robotic chest surgery to see if those who get the b…

This study looks at whether emotional disorders like anxiety or depression impact how well liver cancer patients respond to immunotherapy. Researchers will follow 651 adults with newly diagnosed liver cancer who are starting treatment. The goal is to see if emotional health affec…

This study reviews past medical records of people with Familial Mediterranean Fever (FMF) to see how well different drugs work and how safe they are in everyday use. About 12 participants will be included. The goal is to learn which treatments help most in real life, not just in …

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung problems after hip surgery in older adults. It involves 40 people aged 65 and older who have waited more than 48 hours for surgery. Researchers will measure oxygen levels and lung function to …

This study explores a new, non-invasive MRI method to monitor kidney health after a transplant. Instead of relying on blood tests or invasive biopsies, the MRI measures blood flow and oxygen levels in the kidney. The goal is to detect problems earlier and more accurately, improvi…

This study aims to find new biomarkers in blood, spinal fluid, urine, and stool that can help predict who is at risk for ischemic stroke and how the disease will progress. Researchers will follow 7,000 participants—including stroke patients and healthy volunteers—for up to 4 year…