Could poop transplants spare kids with Crohn's from strong drugs?
NCT ID NCT05321758
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This study tests whether repeated fecal microbiota transplants (FMT) combined with a special liquid diet can safely control active Crohn's disease in children aged 2–16 who are newly diagnosed. The goal is to see if this approach can achieve remission and heal the gut lining without using standard immunosuppressive drugs. Fifty children will receive multiple FMT courses along with partial enteral nutrition, and their outcomes will be measured by symptom scores and colonoscopy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fecal microbiota transplantation (FMT) plus partial enteral nutrition
- What this could lead to
- If successful, this approach could offer a drug-sparing first-line treatment for children with Crohn's disease, potentially reducing the need for immunosuppressants.
- What could go wrong
- This is a small, early-phase study with no control group, so results may not be conclusive. FMT carries risks like fever, abdominal pain, or infection.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Tongji Hospital
RECRUITINGWuhan, Hubei, 430030, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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