Tongji Hospital

This study tests whether a computer model can help decide which liver cancer patients should receive immunotherapy (PD-1 inhibitors) after surgery to prevent the cancer from coming back. About 300 adults who had their liver cancer completely removed will be enrolled. The goal is …

This study tests a new treatment called ACE1831 for people with lupus that is active despite standard therapies. ACE1831 uses immune cells from healthy donors to try to control the disease. The study will check if the treatment is safe and if it reduces lupus symptoms. It involve…

This study tests a new combination of four treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The goal is to see if adding a blood pressure drug (carvedilol) to standard cancer therap…

This study tests whether a robotic system can perform liver surgery from a distance as safely and effectively as when the surgeon is in the same room. About 102 adults needing liver surgery will be randomly assigned to either remote or local robotic surgery. The main goal is to s…

This study looks at whether giving a bone-strengthening drug (denosumab) early, along with standard cancer therapy, can prevent bone problems like fractures or spinal cord compression in people with liver cancer that has spread to the bones. About 50 adults will be randomly assig…

This study tests whether combining lenvatinib (a daily pill) with a PD-1 inhibitor (an immunotherapy given by IV every 3 weeks) can shrink or stop advanced solid tumors that have a specific genetic change called 11q13 amplification. About 60 adults with various cancers (like esop…

This study tests a traditional Chinese medicine called Calculus Bovis Sativus (CBS) in 300 people who have had a brain hemorrhage (bleeding in the brain). CBS is made from bezoar ingredients and is thought to reduce inflammation and protect brain cells. Participants will take CBS…

This early-stage study tests a new type of CAR-T cell therapy for adults with B-cell acute lymphoblastic leukemia or non-Hodgkin lymphoma that has not responded to standard treatments. Participants receive a single infusion of immune cells designed to attack two cancer targets (C…

This study tests whether a mix of immunotherapy (toripalimab), targeted therapy (RC48-ADC), and radiation can help people with HER2-positive muscle-invasive bladder cancer keep their bladder after initial chemotherapy. About 45 adults with stage T2-T4aN0M0 disease will receive th…

This early-phase study tests a new type of cell therapy called CAR-ITNK for people with relapsed or refractory acute myeloid leukemia (AML), a blood cancer that has not responded to standard treatments. The therapy uses specially engineered immune cells that target two proteins, …

This study tests whether a HUAWEI smartwatch with artificial intelligence can improve monitoring and management of heart attack patients during a 3-month outpatient rehab program. About 1,050 adults aged 18-69 who recently had a heart attack and a stent placed will be split into …

This study looks at 280 adults with liver cancer that has spread outside the liver. It compares standard drug therapy alone versus surgery to remove the main liver tumor followed by the same drug therapy. The goal is to see if adding surgery helps people live longer.

This study looks at two different treatment combinations for people with liver cancer that cannot be removed by surgery. One group gets a standard liver-directed therapy (TACE) plus two drugs, while the other gets a different liver-directed therapy (HAIC) plus the same two drugs.…

This study tests a new daily pill called ivarmacitinib for people with rheumatoid arthritis (RA) who did not get better with standard first treatments. The goal is to see if it can reduce joint pain and swelling and control the disease. About 100 adults with moderate to severe RA…

This study tests a new drug called firsekibart in 30 adults with a severe form of systemic sclerosis (scleroderma) that affects the skin. The goal is to see if the drug can reduce skin thickening and improve overall disease symptoms. Participants will receive the drug and be comp…

This study tests the drug glimepiride in about 1,484 adults with type 2 diabetes and chronic heart failure with reduced pumping ability. The goal is to see if the drug can lower the risk of heart-related death, need for a heart transplant, or worsening heart failure that requires…

This study tests a combination of three drugs—firsekibart, tislelizumab, and lenvatinib—in 25 adults with advanced liver cancer that has a TP53 gene mutation and has not responded to previous immunotherapy. The goal is to see if the combination can shrink tumors and control the d…

This study looks at people with liver cancer that has spread to a few spots outside the liver. All participants first get a combination of two drugs (sintilimab and lenvatinib). Those whose cancer is controlled are then randomly assigned to either continue the drugs alone or also…

This study tests an artificial intelligence (AI) tool that reads MRI scans to tell the difference between common, non-cancerous uterine fibroids and a rare but aggressive cancer called uterine sarcoma. Researchers will enroll 500 women who are scheduled for surgery or long-term f…

This study is testing a new blood test that looks for specific DNA changes to see if liver cancer has come back after treatment. About 162 adults who have had or will have surgery, transplant, or other procedures for liver cancer will give blood samples before and after treatment…

This study will test whether a virtual reality (VR) mindfulness program can help patients feel less anxious and experience less pain during minimally invasive vascular surgery done under local anesthesia. About 160 adults will be randomly assigned to either receive the VR mindful…

This study looks at whether a drug called osellidine can control pain during hysteroscopic surgery better and with fewer side effects than standard painkillers. About 310 women having day surgery will be observed to compare pain relief, side effects like breathing problems or con…

This early-stage trial will test whether a Chinese herbal formula called TJAOA103 can safely relieve common menopause symptoms like vaginal dryness, itching, and pain during sex. About 113 women aged 45 to 70 with moderate-to-severe symptoms will take the herbal granules twice da…

This study looks for biological markers that can predict bladder injury caused by radiation therapy. Researchers will collect samples from 220 adults receiving high-dose abdominal radiation. The goal is to create a model that helps doctors identify patients at risk for bladder da…

This study aims to find biological markers that can predict radiation-induced intestinal injury in people receiving high-dose abdominal radiation. Researchers will collect samples from 220 adults to develop a model that forecasts this side effect. The goal is to better understand…

This study will test a computer model that predicts infertility risk in women with uterine fibroids. Researchers will follow over 7,000 women aged 20-50 who want to get pregnant and have fibroids. The goal is to see if the model can accurately predict who will have trouble concei…

This study looks at whether a low-carbohydrate diet helps women with advanced ovarian cancer who are taking a type of maintenance therapy called PARP inhibitors. Researchers will review medical records and ask about eating habits from 600 women across 14 hospitals in China. The g…

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday clinical practice. Researchers will collect long-te…

This study looks at whether a simple blood test can detect leftover cancer cells after liver cancer surgery. It involves 276 adults with high-risk liver cancer. The goal is to see if the test can predict if the cancer will come back and who might benefit from extra immunotherapy …

This study looks at how different surgical tools used during lung cancer surgery affect coughing after the operation. About 248 adults having lung surgery will be randomly assigned to receive either energy-based or mechanical cutting tools. The goal is to find out which tool caus…