New study aims to prevent bone fractures in liver cancer patients

NCT ID NCT07537972

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether starting denosumab early, along with a standard immunotherapy, can prevent bone problems like fractures or spinal cord compression in people with liver cancer that has spread to the bones. About 50 adults with liver cancer and bone metastases will be randomly assigned to get either early denosumab plus immunotherapy or immunotherapy alone with rescue treatment only if needed. The goal is to see which approach better delays bone complications and improves quality of life.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma metastatic carcinoma in the bone

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430030, China