Can engineered immune cells tame multiple sclerosis?
NCT ID NCT07756268
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests an experimental therapy called SYS6020 for people with relapsing or progressive multiple sclerosis that hasn't responded well to standard treatments. SYS6020 uses a patient's own immune cells, engineered to target and potentially reduce harmful B cells involved in the disease. Participants receive six weekly infusions of these modified cells. The study aims to see if the treatment is safe, tolerable, and whether it can slow disability progression or reduce relapse rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SYS6020 injection, a personalized CAR-T cell therapy targeting BCMA, given as six weekly infusions
- What this could lead to
- If successful, this could offer a new way to slow or halt disability progression in multiple sclerosis, potentially reducing relapses and improving quality of life.
- What could go wrong
- This is an early-stage, small trial (up to 25 participants). CAR-T therapies carry risks like cytokine release syndrome and infections, and the treatment may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Tongji Hospital, Tongji Medical College of Hust
Wuhan, Hubei, 430000, China
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