Tongji Hospital

This phase 2 trial tests a combination of four drugs—pirtobrutinib, sintilimab, rituximab, and high-dose methotrexate—as a first treatment for adults with newly diagnosed primary central nervous system lymphoma (PCNSL). About 77 participants will choose either this experimental c…

This study looks at whether giving a drug called somatostatin along with a clear liquid diet for a week after rectal cancer surgery can prevent dangerous bowel leaks as well as a temporary stoma (a bag outside the body). About 72 adults with low or mid rectal cancer will be rando…

This phase 3 trial tests whether a new immunotherapy drug (QL1706) combined with bevacizumab can slow cancer growth better than standard chemotherapy in women with advanced ovarian clear cell carcinoma. About 226 participants will be randomly assigned to receive either the experi…

This early-phase study tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and calm the immune system in people with neurological autoimmune diseases like multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinat…

This study tests a combination of two drugs—tislelizumab (an immunotherapy) and huaier granule (a traditional Chinese medicine)—as a first treatment for people with advanced liver cancer that cannot be surgically removed. About 94 adults will receive this combination to see if it…

This early-phase trial is testing a new cell therapy called QH103 for people with severe autoimmune diseases like multiple sclerosis and myasthenia gravis that haven't responded to standard treatments. The therapy uses specially engineered immune cells to target and attack the fa…

This study is testing a drug called glycerol phenylbutyrate in 40 Chinese children with urea cycle disorders, a rare genetic condition that causes dangerous ammonia buildup. The drug aims to help control ammonia levels over 5 years. Researchers will monitor safety and effectivene…

This early-phase trial tests a single dose of AZD0120, a CAR-T cell therapy that targets two immune proteins (CD19 and BCMA), in 12 highly sensitized adults with end-stage kidney disease awaiting a transplant. The goal is to safely reduce the antibodies that make finding a compat…

This study tests a new combination of four drugs—two standard chemotherapies plus an immunotherapy and a cholesterol drug—in people with advanced bile duct cancer. All 29 participants will receive the same treatment. Researchers will check how many patients see their tumors shrin…

This study compares telitacicept, a newer biologic drug, against the standard treatment cyclophosphamide for lupus patients who also have interstitial lung disease (ILD). About 100 adults with early lupus and ILD will receive either telitacicept or cyclophosphamide, plus usual ca…

This study tests whether ciprofol, a newer sedative, can reduce heart injury after lung surgery compared to the standard drug propofol. About 1,058 adults aged 45–80 having video-assisted lung surgery will be randomly assigned to receive one of the two drugs during anesthesia. Th…

This study is testing whether a higher dose (300 mg) of the drug secukinumab (Cosentyx) can safely and effectively reduce symptoms in Chinese adults with active ankylosing spondylitis who have not gotten relief from at least two NSAIDs. One hundred participants will receive eithe…

This early-stage trial tests a modified virus called KD01, given directly into the bladder, to see if it is safe and can fight bladder cancer. The study includes 29 patients with either high-risk non-muscle-invasive bladder cancer or muscle-invasive bladder cancer. Some patients …

This early-stage trial tests a new treatment called NouvSoma001 for people with neuromyelitis optica spectrum disorders (NMOSD), a rare disease that causes inflammation in the eyes and spinal cord. The treatment uses tiny particles from stem cells, given via a spinal injection, t…

This early-phase study tests a single injection of a gene therapy called V001-BCMA for people with autoimmune diseases like lupus that have not responded to standard treatments. The therapy targets and modifies specific immune cells to reduce disease activity. The main goal is to…

This study tests a modified virus (KD01) that targets and kills cancer cells, given alone or with an immunotherapy drug (AK104). It includes 97 women with cervical or endometrial cancer, some of whom have not responded to standard treatments. The goal is to see if the virus is sa…

This study looks at whether two different versions of Angong Niuhuang Pills can help people recover from an acute ischemic stroke. About 100 adults aged 18-80 will take one of the two pill types or receive no pills, and their recovery will be tracked for 84 days. The goal is to s…

This study tests whether a high-MCT (medium-chain triglyceride) formula given before and after Kasai surgery can improve growth and nutrition in infants with biliary atresia. Biliary atresia is a rare liver condition that blocks bile flow, leading to malnutrition. The trial will …

This study is for people with early-stage liver cancer who are scheduled for surgery. Researchers are testing whether an artificial intelligence (AI) tool can predict each patient's risk of the cancer returning. Patients identified as high-risk will receive a combination of chemo…

This study tests a new way to treat a serious type of brain bleed (intracerebral hemorrhage). It compares standard medical care to a minimally invasive procedure that uses a small tube to drain the blood clot and deliver a clot-busting drug (tenecteplase). The goal is to see if t…

This study looks at whether adding a procedure that removes lymphoid tissue in the back of the nose to standard sinus surgery can better control inflammation in people with nasal polyps. Thirty-two adults with nasal polyps will be randomly assigned to get either standard surgery …

This early-stage study is testing a new immune cell therapy called CT1190B CAR-T in 27 adults with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The therapy involves modifying a patient's own immune cells to better recognize and attack cancer cells…

This registry study is tracking 200 people with a rare autoimmune disease called neuromyelitis optica spectrum disorder (NMOSD) who are positive for the AQP4 antibody. Researchers are evaluating how well monoclonal antibody therapies work in real-world settings, focusing on preve…

This study aims to build an AI model that can help doctors diagnose brain diseases like tumors, strokes, and neurodegenerative disorders using MRI scans. Researchers will collect data from 1,000 patients to train and test the AI. The goal is to see if the AI can improve diagnosti…

This study is testing an artificial intelligence model that combines CT scans, tissue images, and patient data to predict whether colorectal cancer will spread to the liver after surgery. Researchers will enroll 160 patients across multiple hospitals and follow them for two years…

This study is testing whether advanced, non-contrast MRI scans can safely and accurately monitor the health of transplanted kidneys. Currently, doctors rely on blood tests and invasive biopsies, which can miss early signs of trouble. Researchers will scan 1000 participants, inclu…

This study tests a new blood test that looks for tiny molecules called MicroRNA in people with breast cancer. The goal is to see how accurate the test is at detecting the disease. Researchers will compare results from 100 participants, including healthy volunteers, to measure the…

This study tests whether getting a flu vaccine can prevent serious heart problems in people who have recently had a heart attack or unstable angina. About 6,620 participants will receive either a flu shot or a placebo and be followed for one year. The goal is to see if the vaccin…

This study tests whether Jinfeng Pill, a traditional Chinese medicine, can safely ease perimenopausal symptoms like hot flashes, insomnia, and mood swings. About 100 women aged 45-55 will take either the pill or a placebo for 12 weeks. Researchers will track symptom changes and e…

This study compares manual acupuncture and electroacupuncture to see which works better for people with long-term constipation. 72 adults will receive 12 weeks of treatment, three times per week. The main goal is to see if bowel movements increase to at least three per week. Rese…

This study tests whether combining a new painkiller (tegileridine) with a nerve block can better control pain after lung surgery. About 118 adults having lung surgery will receive this combo, and researchers will measure their pain levels and recovery. The goal is to find a safer…

This study is for people with advanced bile duct or pancreatic cancer who have significant pain. Researchers want to see if adding a nerve-blocking pain treatment (celiac plexus block) to standard first-line cancer therapy helps control pain and shrink tumors better than standard…

This study looks at two different anesthesia drugs (remimazolam and ciprofol) used during tonsil and adenoid removal in children. The goal is to see which one causes fewer breathing problems like coughing, airway blockages, or low oxygen levels. About 114 children aged 2-12 will …

This study is testing whether a wearable device can give early warning of complications after chest surgery. The device tracks heart rate, oxygen levels, temperature, and activity from hospital admission to 30 days after discharge. Researchers will first use past data to build a …

This study is gathering information from 800 people with liver cancer to track their diagnosis, treatments, and long-term health. The goal is to create a detailed database that helps doctors see what works best in real-world care. Participants must be 18 or older and treated at T…

This study looks at how the laxatives used for colonoscopy preparation change the gut bacteria in people who have had their gallbladder removed. Researchers will compare 10 people with prior gallbladder removal to 10 people with an intact gallbladder. All participants will provid…

This study is developing an artificial intelligence (AI) model to predict the risk of liver metastasis in colorectal cancer patients after curative surgery. Researchers will analyze CT scans, pathology slides, and clinical data from 1,500 patients across multiple hospitals. The g…

This study reviews past medical records of 12 people with Familial Mediterranean Fever to see how well different drugs control symptoms in everyday practice. Researchers will measure symptom improvement using patient ratings. The goal is to understand which treatments work best o…

This study looks at whether emotional disorders like depression and anxiety affect how well immunotherapy works in people with liver cancer. Researchers will follow 651 patients and compare treatment outcomes between those with and without emotional distress. The goal is to under…

This study is looking for biological markers (biomarkers) in blood, urine, spinal fluid, and other samples that could help predict who will have a stroke and how they will recover. Researchers will follow 7,000 people with and without ischemic cerebrovascular disease for up to 4 …

This study aims to create a large database and sample bank to better understand headaches. Researchers will collect health information and treatment records from 50,000 people with headaches. The goal is to develop a system that helps doctors diagnose and treat headaches more pre…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung complications after delayed hip fracture surgery in people aged 65 and older. Forty participants will be assigned to one of the two anesthesia types, and their lung function will be measured a…

This study is testing an artificial intelligence (AI) model to see if it can predict whether early-stage liver cancer will come back within two years after surgery. About 353 adults with early-stage liver cancer will have standard surgery and then be monitored with scans. Their m…

This study is testing a new MRI technology to see if it can accurately assess fatty liver disease without needing a liver biopsy. Researchers will scan 500 patients and compare the MRI results with traditional tests. If it works, it could make diagnosis and monitoring much easier…