Brain blood flow secrets revealed by breathing test

NCT ID NCT04258774

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses MRI scans to see how the brain's blood vessels react when people breathe in extra carbon dioxide. Researchers want to compare healthy adults and those with brain blood vessel diseases. The goal is to learn more about brain blood flow and oxygen use, which could help understand conditions that affect brain health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carbon dioxide (inhaled)
What this could lead to: If successful, this could help doctors better understand how brain blood vessels work in health and disease, potentially guiding future treatments.
What could go wrong: This is an early observational study with only 48 participants. It is not testing a treatment, so direct patient benefits are not expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia Hypercapnia Hyperoxia Hypocapnia Hypoxia, Brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERCAPNIA HYPEROXIA HYPOCAPNIA HYPOXIA, BRAIN

Contacts and locations

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Locations

Washington University of St. Louis

St Louis, Missouri, 63110, United States

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